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Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β

BACKGROUND: The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human neurons to identify potential therapeutic targets for neuroprotection against chronic inflammation. METHODS: Surface immunocytoc...

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Detalles Bibliográficos
Autores principales:	Lee, Paul R., Johnson, Tory P., Gnanapavan, Sharmilee, Giovannoni, Gavin, Wang, Tongguang, Steiner, Joseph P., Medynets, Marie, Vaal, Mark J., Gartner, Valerie, Nath, Avindra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488439/ https://www.ncbi.nlm.nih.gov/pubmed/28655310 http://dx.doi.org/10.1186/s12974-017-0901-y

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