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Effect of BCHE single nucleotide polymorphisms on lipid metabolism markers in women

Butyrylcholinesterase (BChE) activity and polymorphisms in its encoding gene had previously been associated with metabolic traits of obesity. This study investigated the association of three single nucleotide polymorphisms (SNPs) in the BCHE gene: -116G > A (rs1126680), 1615GA (rs1803274), 1914A...

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Autores principales: de Oliveira, Jéssica, Tureck, Luciane Viater, dos Santos, Willian, Saliba, Louise Farah, Schenknecht, Caroline Schovanz, Scaraboto, Débora, Souza, Ricardo Lehtonen R., Furtado-Alle, Lupe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488457/
https://www.ncbi.nlm.nih.gov/pubmed/28497838
http://dx.doi.org/10.1590/1678-4685-GMB-2016-0123
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author de Oliveira, Jéssica
Tureck, Luciane Viater
dos Santos, Willian
Saliba, Louise Farah
Schenknecht, Caroline Schovanz
Scaraboto, Débora
Souza, Ricardo Lehtonen R.
Furtado-Alle, Lupe
author_facet de Oliveira, Jéssica
Tureck, Luciane Viater
dos Santos, Willian
Saliba, Louise Farah
Schenknecht, Caroline Schovanz
Scaraboto, Débora
Souza, Ricardo Lehtonen R.
Furtado-Alle, Lupe
author_sort de Oliveira, Jéssica
collection PubMed
description Butyrylcholinesterase (BChE) activity and polymorphisms in its encoding gene had previously been associated with metabolic traits of obesity. This study investigated the association of three single nucleotide polymorphisms (SNPs) in the BCHE gene: -116G > A (rs1126680), 1615GA (rs1803274), 1914A < G (rs3495), with obesity and lipid metabolism markers, body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride (TG) levels, and BChE enzymatic activity in obese (BMI≥30/n = 226) and non-obese women (BMI < 25/n = 81). BCHE SNPs genotyping was obtained by TaqMan allelic discrimination assay and by RFLP-PCR. Plasmatic BChE activity was measured using propionylthiocholine as substrate. Similar allele frequencies were found in obese and non-obese women for the three studied SNPs (p > 0.05). The dominant and recessive models were tested, and different effects were found. The -116A allele showed a dominant effect in BChE activity reduction in both non-obese and obese women (p = 0.045 and p < 0.001, respectively). The 1914A > G and 1615GA SNPs influenced the TG levels only in obese women. The 1914G and the 1615A alleles were associated with decreased plasma levels of TG. Thus, our results suggest that the obesity condition, characterized by loss of energy homeostasis, is modulated by BCHE polymorphisms.
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spelling pubmed-54884572017-07-11 Effect of BCHE single nucleotide polymorphisms on lipid metabolism markers in women de Oliveira, Jéssica Tureck, Luciane Viater dos Santos, Willian Saliba, Louise Farah Schenknecht, Caroline Schovanz Scaraboto, Débora Souza, Ricardo Lehtonen R. Furtado-Alle, Lupe Genet Mol Biol Human and Medical Genetics Butyrylcholinesterase (BChE) activity and polymorphisms in its encoding gene had previously been associated with metabolic traits of obesity. This study investigated the association of three single nucleotide polymorphisms (SNPs) in the BCHE gene: -116G > A (rs1126680), 1615GA (rs1803274), 1914A < G (rs3495), with obesity and lipid metabolism markers, body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride (TG) levels, and BChE enzymatic activity in obese (BMI≥30/n = 226) and non-obese women (BMI < 25/n = 81). BCHE SNPs genotyping was obtained by TaqMan allelic discrimination assay and by RFLP-PCR. Plasmatic BChE activity was measured using propionylthiocholine as substrate. Similar allele frequencies were found in obese and non-obese women for the three studied SNPs (p > 0.05). The dominant and recessive models were tested, and different effects were found. The -116A allele showed a dominant effect in BChE activity reduction in both non-obese and obese women (p = 0.045 and p < 0.001, respectively). The 1914A > G and 1615GA SNPs influenced the TG levels only in obese women. The 1914G and the 1615A alleles were associated with decreased plasma levels of TG. Thus, our results suggest that the obesity condition, characterized by loss of energy homeostasis, is modulated by BCHE polymorphisms. Sociedade Brasileira de Genética 2017-05-11 2017 /pmc/articles/PMC5488457/ /pubmed/28497838 http://dx.doi.org/10.1590/1678-4685-GMB-2016-0123 Text en Copyright © 2017, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
spellingShingle Human and Medical Genetics
de Oliveira, Jéssica
Tureck, Luciane Viater
dos Santos, Willian
Saliba, Louise Farah
Schenknecht, Caroline Schovanz
Scaraboto, Débora
Souza, Ricardo Lehtonen R.
Furtado-Alle, Lupe
Effect of BCHE single nucleotide polymorphisms on lipid metabolism markers in women
title Effect of BCHE single nucleotide polymorphisms on lipid metabolism markers in women
title_full Effect of BCHE single nucleotide polymorphisms on lipid metabolism markers in women
title_fullStr Effect of BCHE single nucleotide polymorphisms on lipid metabolism markers in women
title_full_unstemmed Effect of BCHE single nucleotide polymorphisms on lipid metabolism markers in women
title_short Effect of BCHE single nucleotide polymorphisms on lipid metabolism markers in women
title_sort effect of bche single nucleotide polymorphisms on lipid metabolism markers in women
topic Human and Medical Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488457/
https://www.ncbi.nlm.nih.gov/pubmed/28497838
http://dx.doi.org/10.1590/1678-4685-GMB-2016-0123
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