Cargando…
The impact of sterile inflammation in acute liver injury
Background: The liver has a number of functions in innate immunity. These functions predispose the liver to innate immune-mediated liver injury when inflammation goes unchecked. Significant progress has been made in the last 25 years on sterile inflammatory liver injury in a number of models; howeve...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Whioce Publishing Pte. Ltd.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488807/ https://www.ncbi.nlm.nih.gov/pubmed/28670626 |
_version_ | 1783246719366987776 |
---|---|
author | Woolbright, Benjamin L. Jaeschke, Hartmut |
author_facet | Woolbright, Benjamin L. Jaeschke, Hartmut |
author_sort | Woolbright, Benjamin L. |
collection | PubMed |
description | Background: The liver has a number of functions in innate immunity. These functions predispose the liver to innate immune-mediated liver injury when inflammation goes unchecked. Significant progress has been made in the last 25 years on sterile inflammatory liver injury in a number of models; however, a great deal of controversy and many questions about the nature of sterile inflammation still exist. Aim: The goal of this article is to review sterile inflammatory liver injury using both a basic approach to what constitutes the inflammatory injury, and through examination of current models of liver injury and inflammation. This information will be tied to human patient conditions when appropriate. Relevance for patients: Inflammation is one of the most critical factors for managing in-patient liver disease in a number of scenarios. More information is needed for both scientists and clinicians to develop rational treatments. |
format | Online Article Text |
id | pubmed-5488807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Whioce Publishing Pte. Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54888072017-06-28 The impact of sterile inflammation in acute liver injury Woolbright, Benjamin L. Jaeschke, Hartmut J Clin Transl Res Review Background: The liver has a number of functions in innate immunity. These functions predispose the liver to innate immune-mediated liver injury when inflammation goes unchecked. Significant progress has been made in the last 25 years on sterile inflammatory liver injury in a number of models; however, a great deal of controversy and many questions about the nature of sterile inflammation still exist. Aim: The goal of this article is to review sterile inflammatory liver injury using both a basic approach to what constitutes the inflammatory injury, and through examination of current models of liver injury and inflammation. This information will be tied to human patient conditions when appropriate. Relevance for patients: Inflammation is one of the most critical factors for managing in-patient liver disease in a number of scenarios. More information is needed for both scientists and clinicians to develop rational treatments. Whioce Publishing Pte. Ltd. 2017-02-12 /pmc/articles/PMC5488807/ /pubmed/28670626 Text en Copyright © 2017, Whioce Publishing Pte. Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This work is licensed under a Creative Commons Attribution 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Review Woolbright, Benjamin L. Jaeschke, Hartmut The impact of sterile inflammation in acute liver injury |
title | The impact of sterile inflammation in acute liver injury |
title_full | The impact of sterile inflammation in acute liver injury |
title_fullStr | The impact of sterile inflammation in acute liver injury |
title_full_unstemmed | The impact of sterile inflammation in acute liver injury |
title_short | The impact of sterile inflammation in acute liver injury |
title_sort | impact of sterile inflammation in acute liver injury |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488807/ https://www.ncbi.nlm.nih.gov/pubmed/28670626 |
work_keys_str_mv | AT woolbrightbenjaminl theimpactofsterileinflammationinacuteliverinjury AT jaeschkehartmut theimpactofsterileinflammationinacuteliverinjury AT woolbrightbenjaminl impactofsterileinflammationinacuteliverinjury AT jaeschkehartmut impactofsterileinflammationinacuteliverinjury |