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In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia
Hyperthermia used as an adjuvant with chemotherapy is highly promising in the treatment of certain cancers. Currently, the small molecule drugs used in combination with hyperthermia were not designed for this application. Herein, we report the evaluation of a chlorambucil and a ruthenium compound mo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489028/ https://www.ncbi.nlm.nih.gov/pubmed/28706667 http://dx.doi.org/10.1039/c5sc00613a |
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author | Clavel, Catherine M. Nowak-Sliwinska, Patrycja Păunescu, Emilia Griffioen, Arjan W. Dyson, Paul J. |
author_facet | Clavel, Catherine M. Nowak-Sliwinska, Patrycja Păunescu, Emilia Griffioen, Arjan W. Dyson, Paul J. |
author_sort | Clavel, Catherine M. |
collection | PubMed |
description | Hyperthermia used as an adjuvant with chemotherapy is highly promising in the treatment of certain cancers. Currently, the small molecule drugs used in combination with hyperthermia were not designed for this application. Herein, we report the evaluation of a chlorambucil and a ruthenium compound modified with a long fluorous chain, which exhibit thermoresponsive activity in colorectal adenocarcinoma xenografts in athymic mice in combination with mild hyperthermia (42 °C). Intraperitoneal injection of the derivatives followed by local hyperthermia showed a synergistic tumor growth reduction by 79% and 90% for the chlorambucil and ruthenium-based derivatives, respectively, with the latter exhibiting a higher synergy in combination with hyperthermia compared to the monotherapies. Histological analysis shows that both derivatives in combination with hyperthermia significantly decrease the number of proliferating tumor cells. |
format | Online Article Text |
id | pubmed-5489028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-54890282017-07-13 In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia Clavel, Catherine M. Nowak-Sliwinska, Patrycja Păunescu, Emilia Griffioen, Arjan W. Dyson, Paul J. Chem Sci Chemistry Hyperthermia used as an adjuvant with chemotherapy is highly promising in the treatment of certain cancers. Currently, the small molecule drugs used in combination with hyperthermia were not designed for this application. Herein, we report the evaluation of a chlorambucil and a ruthenium compound modified with a long fluorous chain, which exhibit thermoresponsive activity in colorectal adenocarcinoma xenografts in athymic mice in combination with mild hyperthermia (42 °C). Intraperitoneal injection of the derivatives followed by local hyperthermia showed a synergistic tumor growth reduction by 79% and 90% for the chlorambucil and ruthenium-based derivatives, respectively, with the latter exhibiting a higher synergy in combination with hyperthermia compared to the monotherapies. Histological analysis shows that both derivatives in combination with hyperthermia significantly decrease the number of proliferating tumor cells. Royal Society of Chemistry 2015-05-01 2015-03-17 /pmc/articles/PMC5489028/ /pubmed/28706667 http://dx.doi.org/10.1039/c5sc00613a Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Chemistry Clavel, Catherine M. Nowak-Sliwinska, Patrycja Păunescu, Emilia Griffioen, Arjan W. Dyson, Paul J. In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia |
title |
In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia |
title_full |
In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia |
title_fullStr |
In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia |
title_full_unstemmed |
In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia |
title_short |
In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia |
title_sort | in vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489028/ https://www.ncbi.nlm.nih.gov/pubmed/28706667 http://dx.doi.org/10.1039/c5sc00613a |
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