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The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome

Semaphorin3A is a secreted protein known to be involved in organogenesis, immune responses and cancer. In the kidney, semaphorin3A is expressed in the glomerular podocytes, distal tubules and collecting tubules, and believed to play a role in the regulation of the kidney development and function. We...

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Autores principales: Inoue-Torii, Akiko, Kitamura, Shinji, Wada, Jun, Tsuji, Kenji, Makino, Hirofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489052/
https://www.ncbi.nlm.nih.gov/pubmed/28790860
http://dx.doi.org/10.2147/IJNRD.S132980
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author Inoue-Torii, Akiko
Kitamura, Shinji
Wada, Jun
Tsuji, Kenji
Makino, Hirofumi
author_facet Inoue-Torii, Akiko
Kitamura, Shinji
Wada, Jun
Tsuji, Kenji
Makino, Hirofumi
author_sort Inoue-Torii, Akiko
collection PubMed
description Semaphorin3A is a secreted protein known to be involved in organogenesis, immune responses and cancer. In the kidney, semaphorin3A is expressed in the glomerular podocytes, distal tubules and collecting tubules, and believed to play a role in the regulation of the kidney development and function. We examined the serum and urinary semaphorin3A levels in 72 patients with renal disease and 5 healthy volunteers. The patients had been diagnosed with thin basement membrane disease (n=4), minimal change nephrotic syndrome (MCNS; n=22), IgA nephritis (n=21), membranous nephropathy (n=16) and focal segmental glomerular sclerosis (n=9). The level of urinary semaphorin3A in MCNS patients tended to be relatively high among all disease groups. We also investigated the urinary semaphorin3A level in 7 patients with MCNS from disease onset to remission during the drug therapy. MCNS patients in pre-remission states had higher urinary semaphorin3A levels than those in post-remission states receiving immunosuppressive therapies. These results suggested that the urinary semaphorin3A level correlates with the MCNS activity. Semaphorin3A has the potential as a biomarker for MCNS to clarify the reactivity for therapy and may be useful in examining other glomerular diseases with proteinuria as well.
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spelling pubmed-54890522017-08-08 The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome Inoue-Torii, Akiko Kitamura, Shinji Wada, Jun Tsuji, Kenji Makino, Hirofumi Int J Nephrol Renovasc Dis Original Research Semaphorin3A is a secreted protein known to be involved in organogenesis, immune responses and cancer. In the kidney, semaphorin3A is expressed in the glomerular podocytes, distal tubules and collecting tubules, and believed to play a role in the regulation of the kidney development and function. We examined the serum and urinary semaphorin3A levels in 72 patients with renal disease and 5 healthy volunteers. The patients had been diagnosed with thin basement membrane disease (n=4), minimal change nephrotic syndrome (MCNS; n=22), IgA nephritis (n=21), membranous nephropathy (n=16) and focal segmental glomerular sclerosis (n=9). The level of urinary semaphorin3A in MCNS patients tended to be relatively high among all disease groups. We also investigated the urinary semaphorin3A level in 7 patients with MCNS from disease onset to remission during the drug therapy. MCNS patients in pre-remission states had higher urinary semaphorin3A levels than those in post-remission states receiving immunosuppressive therapies. These results suggested that the urinary semaphorin3A level correlates with the MCNS activity. Semaphorin3A has the potential as a biomarker for MCNS to clarify the reactivity for therapy and may be useful in examining other glomerular diseases with proteinuria as well. Dove Medical Press 2017-06-22 /pmc/articles/PMC5489052/ /pubmed/28790860 http://dx.doi.org/10.2147/IJNRD.S132980 Text en © 2017 Inoue-Torii et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Inoue-Torii, Akiko
Kitamura, Shinji
Wada, Jun
Tsuji, Kenji
Makino, Hirofumi
The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome
title The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome
title_full The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome
title_fullStr The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome
title_full_unstemmed The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome
title_short The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome
title_sort level of urinary semaphorin3a is associated with disease activity in patients with minimal change nephrotic syndrome
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489052/
https://www.ncbi.nlm.nih.gov/pubmed/28790860
http://dx.doi.org/10.2147/IJNRD.S132980
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