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Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions

Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated relationships between varianc...

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Detalles Bibliográficos
Autores principales:	Shungin, Dmitry, Deng, Wei Q., Varga, Tibor V., Luan, Jian'an, Mihailov, Evelin, Metspalu, Andres, Morris, Andrew P., Forouhi, Nita G., Lindgren, Cecilia, Magnusson, Patrik K. E., Pedersen, Nancy L., Hallmans, Göran, Chu, Audrey Y., Justice, Anne E., Graff, Mariaelisa, Winkler, Thomas W., Rose, Lynda M., Langenberg, Claudia, Cupples, L. Adrienne, Ridker, Paul M., Wareham, Nicholas J., Ong, Ken K., Loos, Ruth J. F., Chasman, Daniel I., Ingelsson, Erik, Kilpeläinen, Tuomas O., Scott, Robert A., Mägi, Reedik, Paré, Guillaume, Franks, Paul W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489225/ https://www.ncbi.nlm.nih.gov/pubmed/28614350 http://dx.doi.org/10.1371/journal.pgen.1006812

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