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Patients with colorectal cancer associated with Lynch syndrome and MLH1 promoter hypermethylation have similar prognoses

PURPOSE: Mismatch repair deficient (dMMR) colorectal cancer (CRC) is caused by Lynch syndrome (LS) in 3% and sporadic inactivation of MLH1 by hypermethylation (MLH1-hm) in 12% of CRC cases. It is not clear whether outcomes between LS-associated and MLH1-hm CRC differ. The objective of this study was...

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Detalles Bibliográficos
Autores principales:	Haraldsdottir, Sigurdis, Hampel, Heather, Wu, Christina, Weng, Daniel Y., Shields, Peter G., Frankel, Wendy L., Pan, Xueliang, de la Chapelle, Albert, Goldberg, Richard M, Bekaii-Saab, Tanios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489337/ https://www.ncbi.nlm.nih.gov/pubmed/26866578 http://dx.doi.org/10.1038/gim.2015.184

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