PGBD5 promotes site-specific oncogenic mutations in human tumors

Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly-based whole-genome DNA sequencing, we...

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Detalles Bibliográficos
Autores principales: Henssen, Anton G., Koche, Richard, Zhuang, Jiali, Jiang, Eileen, Reed, Casie, Eisenberg, Amy, Still, Eric, MacArthur, Ian C., Rodríguez-Fos, Elias, Gonzalez, Santiago, Puiggròs, Montserrat, Blackford, Andrew N., Mason, Christopher E., de Stanchina, Elisa, Gönen, Mithat, Emde, Anne-Katrin, Shah, Minita, Arora, Kanika, Reeves, Catherine, Socci, Nicholas D., Perlman, Elizabeth, Antonescu, Cristina R., Roberts, Charles W. M., Steen, Hanno, Mullen, Elizabeth, Jackson, Stephen P., Torrents, David, Weng, Zhiping, Armstrong, Scott A., Kentsis, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489359/
https://www.ncbi.nlm.nih.gov/pubmed/28504702
http://dx.doi.org/10.1038/ng.3866

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