Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission

Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO(2)-induced ischemia and that LA...

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Autores principales: Hennebelle, Marie, Zhang, Zhichao, Metherel, Adam H., Kitson, Alex P., Otoki, Yurika, Richardson, Christine E., Yang, Jun, Lee, Kin Sing Stephen, Hammock, Bruce D., Zhang, Liang, Bazinet, Richard P., Taha, Ameer Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489485/
https://www.ncbi.nlm.nih.gov/pubmed/28659576
http://dx.doi.org/10.1038/s41598-017-02914-7
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author Hennebelle, Marie
Zhang, Zhichao
Metherel, Adam H.
Kitson, Alex P.
Otoki, Yurika
Richardson, Christine E.
Yang, Jun
Lee, Kin Sing Stephen
Hammock, Bruce D.
Zhang, Liang
Bazinet, Richard P.
Taha, Ameer Y.
author_facet Hennebelle, Marie
Zhang, Zhichao
Metherel, Adam H.
Kitson, Alex P.
Otoki, Yurika
Richardson, Christine E.
Yang, Jun
Lee, Kin Sing Stephen
Hammock, Bruce D.
Zhang, Liang
Bazinet, Richard P.
Taha, Ameer Y.
author_sort Hennebelle, Marie
collection PubMed
description Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO(2)-induced ischemia and that LA-derived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke.
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spelling pubmed-54894852017-06-30 Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission Hennebelle, Marie Zhang, Zhichao Metherel, Adam H. Kitson, Alex P. Otoki, Yurika Richardson, Christine E. Yang, Jun Lee, Kin Sing Stephen Hammock, Bruce D. Zhang, Liang Bazinet, Richard P. Taha, Ameer Y. Sci Rep Article Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO(2)-induced ischemia and that LA-derived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke. Nature Publishing Group UK 2017-06-28 /pmc/articles/PMC5489485/ /pubmed/28659576 http://dx.doi.org/10.1038/s41598-017-02914-7 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hennebelle, Marie
Zhang, Zhichao
Metherel, Adam H.
Kitson, Alex P.
Otoki, Yurika
Richardson, Christine E.
Yang, Jun
Lee, Kin Sing Stephen
Hammock, Bruce D.
Zhang, Liang
Bazinet, Richard P.
Taha, Ameer Y.
Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
title Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
title_full Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
title_fullStr Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
title_full_unstemmed Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
title_short Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
title_sort linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489485/
https://www.ncbi.nlm.nih.gov/pubmed/28659576
http://dx.doi.org/10.1038/s41598-017-02914-7
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