Potent in vitro and in vivo antifungal activity of a small molecule host defense peptide mimic through a membrane-active mechanism

Lethal systemic fungal infections of Candida species are increasingly common, especially in immune compromised patients. By in vitro screening of small molecule mimics of naturally occurring host defense peptides (HDP), we have identified several active antifungal molecules, which also exhibited pot...

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Detalles Bibliográficos
Autores principales: Menzel, Lorenzo P., Chowdhury, Hossain Mobaswar, Masso-Silva, Jorge Adrian, Ruddick, William, Falkovsky, Klaudia, Vorona, Rafael, Malsbary, Andrew, Cherabuddi, Kartikeya, Ryan, Lisa K., DiFranco, Kristina M., Brice, David C., Costanzo, Michael J., Weaver, Damian, Freeman, Katie B., Scott, Richard W., Diamond, Gill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489528/
https://www.ncbi.nlm.nih.gov/pubmed/28659617
http://dx.doi.org/10.1038/s41598-017-04462-6

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