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Residual effects of eszopiclone and placebo in healthy elderly subjects: a randomized double-blind study
Next-day residual effects are a common problem with current hypnotics. The purpose of the present study was to evaluate the residual effects of eszopiclone on the physical and cognitive functions of healthy elderly people in the early morning and the day following drug administration. Four men and s...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Japan
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489573/ https://www.ncbi.nlm.nih.gov/pubmed/28680342 http://dx.doi.org/10.1007/s41105-017-0101-2 |
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author | Takahashi, Jun Kanbayashi, Takashi Ito Uemura, Sachiko Sagawa, Youhei Tsutsui, Kou Takahashi, Yuya Omori, Yuki Imanishi, Aya Takeshima, Masahiro Satake, Masahiro Shimizu, Tetsuo |
author_facet | Takahashi, Jun Kanbayashi, Takashi Ito Uemura, Sachiko Sagawa, Youhei Tsutsui, Kou Takahashi, Yuya Omori, Yuki Imanishi, Aya Takeshima, Masahiro Satake, Masahiro Shimizu, Tetsuo |
author_sort | Takahashi, Jun |
collection | PubMed |
description | Next-day residual effects are a common problem with current hypnotics. The purpose of the present study was to evaluate the residual effects of eszopiclone on the physical and cognitive functions of healthy elderly people in the early morning and the day following drug administration. Four men and six women aged 63–72 years were administered eszopiclone 1 mg or placebo in a randomized, double-blind and crossover design. Measures of objective parameters and subjective ratings were obtained at 4:00, 6:00, and every 2 h from 6:00 to 16:00 hours. For the timed up-and-go test, the main effects of time were seen. For the critical flicker fusion, eszopiclone had significantly worse results compared to placebo in early morning (4:00). There were no significant differences between eszopiclone and placebo in other objective assessments. For the sleep latency, eszopiclone had significantly shorter results compared to placebo (eszopiclone vs placebo = 28.4 vs 52.5 min, p = 0.047). Feeling of deep sleep and the number of wake after sleep onset did not show any significant differences between eszopiclone and placebo. Based on the above results, the changes of physical and cognitive functions in the healthy elderly after taking hypnotics, it was found that eszopiclone 1 mg is likely to be unharmful for the healthy elderly. Further studies of elderly insomniacs with midnight awakenings are needed. |
format | Online Article Text |
id | pubmed-5489573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-54895732017-07-03 Residual effects of eszopiclone and placebo in healthy elderly subjects: a randomized double-blind study Takahashi, Jun Kanbayashi, Takashi Ito Uemura, Sachiko Sagawa, Youhei Tsutsui, Kou Takahashi, Yuya Omori, Yuki Imanishi, Aya Takeshima, Masahiro Satake, Masahiro Shimizu, Tetsuo Sleep Biol Rhythms Original Article Next-day residual effects are a common problem with current hypnotics. The purpose of the present study was to evaluate the residual effects of eszopiclone on the physical and cognitive functions of healthy elderly people in the early morning and the day following drug administration. Four men and six women aged 63–72 years were administered eszopiclone 1 mg or placebo in a randomized, double-blind and crossover design. Measures of objective parameters and subjective ratings were obtained at 4:00, 6:00, and every 2 h from 6:00 to 16:00 hours. For the timed up-and-go test, the main effects of time were seen. For the critical flicker fusion, eszopiclone had significantly worse results compared to placebo in early morning (4:00). There were no significant differences between eszopiclone and placebo in other objective assessments. For the sleep latency, eszopiclone had significantly shorter results compared to placebo (eszopiclone vs placebo = 28.4 vs 52.5 min, p = 0.047). Feeling of deep sleep and the number of wake after sleep onset did not show any significant differences between eszopiclone and placebo. Based on the above results, the changes of physical and cognitive functions in the healthy elderly after taking hypnotics, it was found that eszopiclone 1 mg is likely to be unharmful for the healthy elderly. Further studies of elderly insomniacs with midnight awakenings are needed. Springer Japan 2017-05-19 2017 /pmc/articles/PMC5489573/ /pubmed/28680342 http://dx.doi.org/10.1007/s41105-017-0101-2 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Takahashi, Jun Kanbayashi, Takashi Ito Uemura, Sachiko Sagawa, Youhei Tsutsui, Kou Takahashi, Yuya Omori, Yuki Imanishi, Aya Takeshima, Masahiro Satake, Masahiro Shimizu, Tetsuo Residual effects of eszopiclone and placebo in healthy elderly subjects: a randomized double-blind study |
title | Residual effects of eszopiclone and placebo in healthy elderly subjects: a randomized double-blind study |
title_full | Residual effects of eszopiclone and placebo in healthy elderly subjects: a randomized double-blind study |
title_fullStr | Residual effects of eszopiclone and placebo in healthy elderly subjects: a randomized double-blind study |
title_full_unstemmed | Residual effects of eszopiclone and placebo in healthy elderly subjects: a randomized double-blind study |
title_short | Residual effects of eszopiclone and placebo in healthy elderly subjects: a randomized double-blind study |
title_sort | residual effects of eszopiclone and placebo in healthy elderly subjects: a randomized double-blind study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489573/ https://www.ncbi.nlm.nih.gov/pubmed/28680342 http://dx.doi.org/10.1007/s41105-017-0101-2 |
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