Cargando…

Health-Related Quality of Life in Adult Patients with Common Variable Immunodeficiency Disorders and Impact of Treatment

PURPOSE: Common variable immunodeficiency disorder (CVID) is a primary immunodeficiency disease (PIDD) often associated with severe and chronic infections. Patients commonly receive immunoglobulin (Ig) treatment to reduce the cycle of recurrent infection and improve physical functioning. However, ho...

Descripción completa

Detalles Bibliográficos
Autores principales: Rider, Nicholas L., Kutac, Carleigh, Hajjar, Joud, Scalchunes, Chris, Seeborg, Filiz O., Boyle, Marcia, Orange, Jordan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489588/
https://www.ncbi.nlm.nih.gov/pubmed/28536745
http://dx.doi.org/10.1007/s10875-017-0404-8
_version_ 1783246820416159744
author Rider, Nicholas L.
Kutac, Carleigh
Hajjar, Joud
Scalchunes, Chris
Seeborg, Filiz O.
Boyle, Marcia
Orange, Jordan S.
author_facet Rider, Nicholas L.
Kutac, Carleigh
Hajjar, Joud
Scalchunes, Chris
Seeborg, Filiz O.
Boyle, Marcia
Orange, Jordan S.
author_sort Rider, Nicholas L.
collection PubMed
description PURPOSE: Common variable immunodeficiency disorder (CVID) is a primary immunodeficiency disease (PIDD) often associated with severe and chronic infections. Patients commonly receive immunoglobulin (Ig) treatment to reduce the cycle of recurrent infection and improve physical functioning. However, how Ig treatment in CVID affects quality of life (QOL) has not been thoroughly evaluated. The purpose of a recent Immune Deficiency Foundation (IDF) mail survey was to assess the factors that are associated with QOL in patients with CVID receiving Ig treatment. METHODS: A 75-question survey developed by the IDF and a 12-item Short Form Health Survey (SF-12) to assess QOL were mailed to adults with CVID. Mean SF-12 scores were compared between patients with CVID and the general US adult population normative sample. RESULTS: Overall, 945 patients with CVID completed the surveys. More than half of the patients (54.9%) received intravenous Ig and 44.9% received subcutaneous Ig treatment. Patients with CVID had significantly lower SF-12 scores compared with the general US population regardless of sex or age (p < 0.05). Route of IgG replacement did not dramatically improve QOL. SF-12 scores were highest in patients with CVID who have well-controlled PIDD, lacked physical impairments, were not bothered by treatment, and received Ig infusions at home. CONCLUSION: These data provide insight into what factors are most associated with physical and mental health, which can serve to improve QOL in patients in this population. Improvements in QOL can result from early detection of disease, limiting digestive system disease, attention to fatigue, and implementation of an individual treatment plan for the patient. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10875-017-0404-8) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-5489588
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-54895882017-07-03 Health-Related Quality of Life in Adult Patients with Common Variable Immunodeficiency Disorders and Impact of Treatment Rider, Nicholas L. Kutac, Carleigh Hajjar, Joud Scalchunes, Chris Seeborg, Filiz O. Boyle, Marcia Orange, Jordan S. J Clin Immunol Original Article PURPOSE: Common variable immunodeficiency disorder (CVID) is a primary immunodeficiency disease (PIDD) often associated with severe and chronic infections. Patients commonly receive immunoglobulin (Ig) treatment to reduce the cycle of recurrent infection and improve physical functioning. However, how Ig treatment in CVID affects quality of life (QOL) has not been thoroughly evaluated. The purpose of a recent Immune Deficiency Foundation (IDF) mail survey was to assess the factors that are associated with QOL in patients with CVID receiving Ig treatment. METHODS: A 75-question survey developed by the IDF and a 12-item Short Form Health Survey (SF-12) to assess QOL were mailed to adults with CVID. Mean SF-12 scores were compared between patients with CVID and the general US adult population normative sample. RESULTS: Overall, 945 patients with CVID completed the surveys. More than half of the patients (54.9%) received intravenous Ig and 44.9% received subcutaneous Ig treatment. Patients with CVID had significantly lower SF-12 scores compared with the general US population regardless of sex or age (p < 0.05). Route of IgG replacement did not dramatically improve QOL. SF-12 scores were highest in patients with CVID who have well-controlled PIDD, lacked physical impairments, were not bothered by treatment, and received Ig infusions at home. CONCLUSION: These data provide insight into what factors are most associated with physical and mental health, which can serve to improve QOL in patients in this population. Improvements in QOL can result from early detection of disease, limiting digestive system disease, attention to fatigue, and implementation of an individual treatment plan for the patient. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10875-017-0404-8) contains supplementary material, which is available to authorized users. Springer US 2017-05-23 2017 /pmc/articles/PMC5489588/ /pubmed/28536745 http://dx.doi.org/10.1007/s10875-017-0404-8 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Rider, Nicholas L.
Kutac, Carleigh
Hajjar, Joud
Scalchunes, Chris
Seeborg, Filiz O.
Boyle, Marcia
Orange, Jordan S.
Health-Related Quality of Life in Adult Patients with Common Variable Immunodeficiency Disorders and Impact of Treatment
title Health-Related Quality of Life in Adult Patients with Common Variable Immunodeficiency Disorders and Impact of Treatment
title_full Health-Related Quality of Life in Adult Patients with Common Variable Immunodeficiency Disorders and Impact of Treatment
title_fullStr Health-Related Quality of Life in Adult Patients with Common Variable Immunodeficiency Disorders and Impact of Treatment
title_full_unstemmed Health-Related Quality of Life in Adult Patients with Common Variable Immunodeficiency Disorders and Impact of Treatment
title_short Health-Related Quality of Life in Adult Patients with Common Variable Immunodeficiency Disorders and Impact of Treatment
title_sort health-related quality of life in adult patients with common variable immunodeficiency disorders and impact of treatment
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489588/
https://www.ncbi.nlm.nih.gov/pubmed/28536745
http://dx.doi.org/10.1007/s10875-017-0404-8
work_keys_str_mv AT ridernicholasl healthrelatedqualityoflifeinadultpatientswithcommonvariableimmunodeficiencydisordersandimpactoftreatment
AT kutaccarleigh healthrelatedqualityoflifeinadultpatientswithcommonvariableimmunodeficiencydisordersandimpactoftreatment
AT hajjarjoud healthrelatedqualityoflifeinadultpatientswithcommonvariableimmunodeficiencydisordersandimpactoftreatment
AT scalchuneschris healthrelatedqualityoflifeinadultpatientswithcommonvariableimmunodeficiencydisordersandimpactoftreatment
AT seeborgfilizo healthrelatedqualityoflifeinadultpatientswithcommonvariableimmunodeficiencydisordersandimpactoftreatment
AT boylemarcia healthrelatedqualityoflifeinadultpatientswithcommonvariableimmunodeficiencydisordersandimpactoftreatment
AT orangejordans healthrelatedqualityoflifeinadultpatientswithcommonvariableimmunodeficiencydisordersandimpactoftreatment