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Immunization with Toxoplasma gondii GRA17 Deletion Mutant Induces Partial Protection and Survival in Challenged Mice

Toxoplasmosis remains a world-threatening disease largely because of the lack of a fully effective vaccine. Here, we created a ΔGRA17 mutant by disrupting the virulence factor GRA17 using CRISPR-Cas9 method. Then, we tested whether ΔGRA17 tachyzoites can be used as a live-attenuated vaccine against...

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Detalles Bibliográficos
Autores principales:	Wang, Jin-Lei, Elsheikha, Hany M., Zhu, Wei-Ning, Chen, Kai, Li, Ting-Ting, Yue, Dong-Mei, Zhang, Xiao-Xuan, Huang, Si-Yang, Zhu, Xing-Quan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489627/ https://www.ncbi.nlm.nih.gov/pubmed/28706518 http://dx.doi.org/10.3389/fimmu.2017.00730

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