Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins

Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins...

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Detalles Bibliográficos
Autores principales: Liu, Juan, Xu, Yangrong, Yang, Jingjing, Wang, Wenzhi, Zhang, Jianqiang, Zhang, Renmei, Meng, Qingguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489761/
https://www.ncbi.nlm.nih.gov/pubmed/28701880
http://dx.doi.org/10.1016/j.jgr.2017.01.001
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author Liu, Juan
Xu, Yangrong
Yang, Jingjing
Wang, Wenzhi
Zhang, Jianqiang
Zhang, Renmei
Meng, Qingguo
author_facet Liu, Juan
Xu, Yangrong
Yang, Jingjing
Wang, Wenzhi
Zhang, Jianqiang
Zhang, Renmei
Meng, Qingguo
author_sort Liu, Juan
collection PubMed
description Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported. The biological activities of ocotillol-type saponins include neuroprotective effect, antimyocardial ischemia, antiinflammatory, antibacterial, and antitumor activities. Owing to their chemical structure, pharmacological actions, and the stereoselective activity on antimyocardial ischemia, ocotillol-type saponins are subjected to extensive consideration. In this review, we sum up the discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.
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spelling pubmed-54897612017-07-12 Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins Liu, Juan Xu, Yangrong Yang, Jingjing Wang, Wenzhi Zhang, Jianqiang Zhang, Renmei Meng, Qingguo J Ginseng Res Review Article Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported. The biological activities of ocotillol-type saponins include neuroprotective effect, antimyocardial ischemia, antiinflammatory, antibacterial, and antitumor activities. Owing to their chemical structure, pharmacological actions, and the stereoselective activity on antimyocardial ischemia, ocotillol-type saponins are subjected to extensive consideration. In this review, we sum up the discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins. Elsevier 2017-07 2017-01-13 /pmc/articles/PMC5489761/ /pubmed/28701880 http://dx.doi.org/10.1016/j.jgr.2017.01.001 Text en © 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Liu, Juan
Xu, Yangrong
Yang, Jingjing
Wang, Wenzhi
Zhang, Jianqiang
Zhang, Renmei
Meng, Qingguo
Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins
title Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins
title_full Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins
title_fullStr Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins
title_full_unstemmed Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins
title_short Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins
title_sort discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489761/
https://www.ncbi.nlm.nih.gov/pubmed/28701880
http://dx.doi.org/10.1016/j.jgr.2017.01.001
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