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A Routine ‘Top-Down’ Approach to Analysis of the Human Serum Proteome

Serum provides a rich source of potential biomarker proteoforms. One of the major obstacles in analysing serum proteomes is detecting lower abundance proteins owing to the presence of hyper-abundant species (e.g., serum albumin and immunoglobulins). Although depletion methods have been used to addre...

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Detalles Bibliográficos
Autores principales: D’Silva, Arlene M., Hyett, Jon A., Coorssen, Jens R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489773/
https://www.ncbi.nlm.nih.gov/pubmed/28587287
http://dx.doi.org/10.3390/proteomes5020013