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Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics

Phagocytes are the main component of innate immunity. They remove pathogens and particles from organisms using their bactericidal tools in the form of both reactive oxygen species and degrading enzymes—contained in granules—that are potentially toxic proteins. Therefore, it is important to investiga...

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Detalles Bibliográficos
Autores principales: Jończyk-Matysiak, Ewa, Weber-Dąbrowska, Beata, Owczarek, Barbara, Międzybrodzki, Ryszard, Łusiak-Szelachowska, Marzanna, Łodej, Norbert, Górski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489797/
https://www.ncbi.nlm.nih.gov/pubmed/28613272
http://dx.doi.org/10.3390/v9060150
Descripción
Sumario:Phagocytes are the main component of innate immunity. They remove pathogens and particles from organisms using their bactericidal tools in the form of both reactive oxygen species and degrading enzymes—contained in granules—that are potentially toxic proteins. Therefore, it is important to investigate the possible interactions between phages and immune cells and avoid any phage side effects on them. Recent progress in knowledge concerning the influence of phages on phagocytes is also important as such interactions may shape the immune response. In this review we have summarized the current knowledge on phage interactions with phagocytes described so far and their potential implications for phage therapy. The data suggesting that phage do not downregulate important phagocyte functions are especially relevant for the concept of phage therapy.