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An Assessment of Early Response to Targeted Therapy via Molecular Imaging: A Pilot Study of 3′-deoxy-3′[(18)F]-Fluorothymidine Positron Emission Tomography (18)F-FLT PET/CT in Prostate Adenocarcinoma

Fluorothymidine is a thymidine analog labeled with fluorine-18 fluorothymidine for positron emission tomography ((18)F-FLT-PET) imaging. Thymidine is a nucleic acid that is used to build DNA. Fluorine-18 fluorothymidine ((18)F-FLT) utilizes the same metabolic pathway as does thymidine but has a very...

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Autores principales: Kairemo, Kalevi, Ravizzini, Gregory C., Macapinlac, Homer A., Subbiah, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489940/
https://www.ncbi.nlm.nih.gov/pubmed/28375169
http://dx.doi.org/10.3390/diagnostics7020020
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author Kairemo, Kalevi
Ravizzini, Gregory C.
Macapinlac, Homer A.
Subbiah, Vivek
author_facet Kairemo, Kalevi
Ravizzini, Gregory C.
Macapinlac, Homer A.
Subbiah, Vivek
author_sort Kairemo, Kalevi
collection PubMed
description Fluorothymidine is a thymidine analog labeled with fluorine-18 fluorothymidine for positron emission tomography ((18)F-FLT-PET) imaging. Thymidine is a nucleic acid that is used to build DNA. Fluorine-18 fluorothymidine ((18)F-FLT) utilizes the same metabolic pathway as does thymidine but has a very low incidence of being incorporated into the DNA (<1%). (18)F-FLT-PET could have a role in the evaluation of response to targeted therapy. We present here a pilot study where we investigated cellular metabolism and proliferation in patients with prostate cancer before and after targeted therapy. Seven patients with Stage IV prostate adenocarcinoma, candidates for targeted therapy inhibiting the hepatocyte growth factor/tyrosine-protein kinase Met (HGF/C-MET) pathway, were included in this study. The HGF/C-MET pathway is implicated in prostate cancer progression, and an evaluation of the inhibition of this pathway could be valuable. (18)F-FLT was performed at baseline and within four weeks post-therapy. Tumor response was assessed semi-quantitatively and using visual response criteria. The range of SUVmax for (18)F-FLT at baseline in the prostate varied from 2.5 to 4.2. This study demonstrated that (18)F-FLT with positron emission tomography/computerized tomography ((18)F-FLT PET/CT) had only limited applications in the early response evaluation of prostate cancer. (18)F-FLT PET/CT may have some utility in the assessment of response in lymph node disease. However, (18)F-FLT PET/CT was not found to be useful in the evaluation of the prostate bed, metastatic skeletal disease, and liver disease.
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spelling pubmed-54899402017-06-30 An Assessment of Early Response to Targeted Therapy via Molecular Imaging: A Pilot Study of 3′-deoxy-3′[(18)F]-Fluorothymidine Positron Emission Tomography (18)F-FLT PET/CT in Prostate Adenocarcinoma Kairemo, Kalevi Ravizzini, Gregory C. Macapinlac, Homer A. Subbiah, Vivek Diagnostics (Basel) Brief Report Fluorothymidine is a thymidine analog labeled with fluorine-18 fluorothymidine for positron emission tomography ((18)F-FLT-PET) imaging. Thymidine is a nucleic acid that is used to build DNA. Fluorine-18 fluorothymidine ((18)F-FLT) utilizes the same metabolic pathway as does thymidine but has a very low incidence of being incorporated into the DNA (<1%). (18)F-FLT-PET could have a role in the evaluation of response to targeted therapy. We present here a pilot study where we investigated cellular metabolism and proliferation in patients with prostate cancer before and after targeted therapy. Seven patients with Stage IV prostate adenocarcinoma, candidates for targeted therapy inhibiting the hepatocyte growth factor/tyrosine-protein kinase Met (HGF/C-MET) pathway, were included in this study. The HGF/C-MET pathway is implicated in prostate cancer progression, and an evaluation of the inhibition of this pathway could be valuable. (18)F-FLT was performed at baseline and within four weeks post-therapy. Tumor response was assessed semi-quantitatively and using visual response criteria. The range of SUVmax for (18)F-FLT at baseline in the prostate varied from 2.5 to 4.2. This study demonstrated that (18)F-FLT with positron emission tomography/computerized tomography ((18)F-FLT PET/CT) had only limited applications in the early response evaluation of prostate cancer. (18)F-FLT PET/CT may have some utility in the assessment of response in lymph node disease. However, (18)F-FLT PET/CT was not found to be useful in the evaluation of the prostate bed, metastatic skeletal disease, and liver disease. MDPI 2017-04-04 /pmc/articles/PMC5489940/ /pubmed/28375169 http://dx.doi.org/10.3390/diagnostics7020020 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Kairemo, Kalevi
Ravizzini, Gregory C.
Macapinlac, Homer A.
Subbiah, Vivek
An Assessment of Early Response to Targeted Therapy via Molecular Imaging: A Pilot Study of 3′-deoxy-3′[(18)F]-Fluorothymidine Positron Emission Tomography (18)F-FLT PET/CT in Prostate Adenocarcinoma
title An Assessment of Early Response to Targeted Therapy via Molecular Imaging: A Pilot Study of 3′-deoxy-3′[(18)F]-Fluorothymidine Positron Emission Tomography (18)F-FLT PET/CT in Prostate Adenocarcinoma
title_full An Assessment of Early Response to Targeted Therapy via Molecular Imaging: A Pilot Study of 3′-deoxy-3′[(18)F]-Fluorothymidine Positron Emission Tomography (18)F-FLT PET/CT in Prostate Adenocarcinoma
title_fullStr An Assessment of Early Response to Targeted Therapy via Molecular Imaging: A Pilot Study of 3′-deoxy-3′[(18)F]-Fluorothymidine Positron Emission Tomography (18)F-FLT PET/CT in Prostate Adenocarcinoma
title_full_unstemmed An Assessment of Early Response to Targeted Therapy via Molecular Imaging: A Pilot Study of 3′-deoxy-3′[(18)F]-Fluorothymidine Positron Emission Tomography (18)F-FLT PET/CT in Prostate Adenocarcinoma
title_short An Assessment of Early Response to Targeted Therapy via Molecular Imaging: A Pilot Study of 3′-deoxy-3′[(18)F]-Fluorothymidine Positron Emission Tomography (18)F-FLT PET/CT in Prostate Adenocarcinoma
title_sort assessment of early response to targeted therapy via molecular imaging: a pilot study of 3′-deoxy-3′[(18)f]-fluorothymidine positron emission tomography (18)f-flt pet/ct in prostate adenocarcinoma
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489940/
https://www.ncbi.nlm.nih.gov/pubmed/28375169
http://dx.doi.org/10.3390/diagnostics7020020
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