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Comparison of the Peripheral Reactive Hyperemia Index with Myocardial Perfusion Reserve by (82)Rb PET/CT in HIV-Infected Patients
After the introduction of antiretroviral therapy (ART) the life expectancy of patients infected with human immunodeficiency virus (HIV) is now approaching that of the general population and the importance of non-AIDS co-morbidities is increasing. Specifically, the risk of coronary artery disease (CA...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489951/ https://www.ncbi.nlm.nih.gov/pubmed/28561781 http://dx.doi.org/10.3390/diagnostics7020031 |
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author | Ørbæk, Mathilde Hasbak, Philip Sejersten Ripa, Rasmus Kjær, Andreas Lebech, Anne-Mette Knudsen, Andreas |
author_facet | Ørbæk, Mathilde Hasbak, Philip Sejersten Ripa, Rasmus Kjær, Andreas Lebech, Anne-Mette Knudsen, Andreas |
author_sort | Ørbæk, Mathilde |
collection | PubMed |
description | After the introduction of antiretroviral therapy (ART) the life expectancy of patients infected with human immunodeficiency virus (HIV) is now approaching that of the general population and the importance of non-AIDS co-morbidities is increasing. Specifically, the risk of coronary artery disease (CAD) seems to be higher in HIV-infected patients and an accurate risk prediction of CAD is of high importance for optimal long term treatment. In this study, we assessed the correlation of the endoPAT, which is an office-based CVD screening tool with the myocardial perfusion reserve by (82)-rubidium PET/CT. We measured the reactive hyperemia index, which is a measure of the endothelial responsiveness, by the use of an endoPAT device (Itamar Medical, Caesarea, Israel) in 48 ART treated HIV-infected patients with high CD 4 cell counts and viral suppression (HIV-RNA < 20 copies/mL), who had previously undergone measurement of the myocardial perfusion reserve by (82)-rubidium PET/CT for study purposes. We found an inverse correlation between the reactive hyperemia index and the myocardial perfusion reserve which most likely indicates different vascular physiology. This study did not find evidence to suggest the immediate implementation of the reactive hyperemia index as a screening tool for early coronary artery disease in well-treated HIV-infected patients pending further validation in larger prospective studies. |
format | Online Article Text |
id | pubmed-5489951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54899512017-06-30 Comparison of the Peripheral Reactive Hyperemia Index with Myocardial Perfusion Reserve by (82)Rb PET/CT in HIV-Infected Patients Ørbæk, Mathilde Hasbak, Philip Sejersten Ripa, Rasmus Kjær, Andreas Lebech, Anne-Mette Knudsen, Andreas Diagnostics (Basel) Article After the introduction of antiretroviral therapy (ART) the life expectancy of patients infected with human immunodeficiency virus (HIV) is now approaching that of the general population and the importance of non-AIDS co-morbidities is increasing. Specifically, the risk of coronary artery disease (CAD) seems to be higher in HIV-infected patients and an accurate risk prediction of CAD is of high importance for optimal long term treatment. In this study, we assessed the correlation of the endoPAT, which is an office-based CVD screening tool with the myocardial perfusion reserve by (82)-rubidium PET/CT. We measured the reactive hyperemia index, which is a measure of the endothelial responsiveness, by the use of an endoPAT device (Itamar Medical, Caesarea, Israel) in 48 ART treated HIV-infected patients with high CD 4 cell counts and viral suppression (HIV-RNA < 20 copies/mL), who had previously undergone measurement of the myocardial perfusion reserve by (82)-rubidium PET/CT for study purposes. We found an inverse correlation between the reactive hyperemia index and the myocardial perfusion reserve which most likely indicates different vascular physiology. This study did not find evidence to suggest the immediate implementation of the reactive hyperemia index as a screening tool for early coronary artery disease in well-treated HIV-infected patients pending further validation in larger prospective studies. MDPI 2017-05-31 /pmc/articles/PMC5489951/ /pubmed/28561781 http://dx.doi.org/10.3390/diagnostics7020031 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ørbæk, Mathilde Hasbak, Philip Sejersten Ripa, Rasmus Kjær, Andreas Lebech, Anne-Mette Knudsen, Andreas Comparison of the Peripheral Reactive Hyperemia Index with Myocardial Perfusion Reserve by (82)Rb PET/CT in HIV-Infected Patients |
title | Comparison of the Peripheral Reactive Hyperemia Index with Myocardial Perfusion Reserve by (82)Rb PET/CT in HIV-Infected Patients |
title_full | Comparison of the Peripheral Reactive Hyperemia Index with Myocardial Perfusion Reserve by (82)Rb PET/CT in HIV-Infected Patients |
title_fullStr | Comparison of the Peripheral Reactive Hyperemia Index with Myocardial Perfusion Reserve by (82)Rb PET/CT in HIV-Infected Patients |
title_full_unstemmed | Comparison of the Peripheral Reactive Hyperemia Index with Myocardial Perfusion Reserve by (82)Rb PET/CT in HIV-Infected Patients |
title_short | Comparison of the Peripheral Reactive Hyperemia Index with Myocardial Perfusion Reserve by (82)Rb PET/CT in HIV-Infected Patients |
title_sort | comparison of the peripheral reactive hyperemia index with myocardial perfusion reserve by (82)rb pet/ct in hiv-infected patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489951/ https://www.ncbi.nlm.nih.gov/pubmed/28561781 http://dx.doi.org/10.3390/diagnostics7020031 |
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