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Cdt1 stabilizes an open MCM ring for helicase loading

ORC, Cdc6 and Cdt1 act together to load hexameric MCM, the motor of the eukaryotic replicative helicase, into double hexamers at replication origins. Here we show that Cdt1 interacts with MCM subunits Mcm2, 4 and 6, which both destabilizes the Mcm2–5 interface and inhibits MCM ATPase activity. Using...

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Detalles Bibliográficos
Autores principales:	Frigola, Jordi, He, Jun, Kinkelin, Kerstin, Pye, Valerie E., Renault, Ludovic, Douglas, Max E., Remus, Dirk, Cherepanov, Peter, Costa, Alessandro, Diffley, John F. X.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490006/ https://www.ncbi.nlm.nih.gov/pubmed/28643783 http://dx.doi.org/10.1038/ncomms15720

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