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Dexmedetomidine as an Anesthetic Adjuvant in Intracranial Surgery
BACKGROUND: The basic principle of neuroanesthesia is to provide hemodynamic stability, provision of optimal operative conditions, maintenance of cerebral perfusion pressure, and cerebral oxygenation. AIM: This study was undertaken to see the effect of dexmedetomidine infusion on hemodynamics and it...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490096/ https://www.ncbi.nlm.nih.gov/pubmed/28663612 http://dx.doi.org/10.4103/0259-1162.194555 |
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author | Batra, Ankita Verma, Reetu Bhatia, V. K. Chandra, Girish Bhushan, Shashi |
author_facet | Batra, Ankita Verma, Reetu Bhatia, V. K. Chandra, Girish Bhushan, Shashi |
author_sort | Batra, Ankita |
collection | PubMed |
description | BACKGROUND: The basic principle of neuroanesthesia is to provide hemodynamic stability, provision of optimal operative conditions, maintenance of cerebral perfusion pressure, and cerebral oxygenation. AIM: This study was undertaken to see the effect of dexmedetomidine infusion on hemodynamics and its ability to act as an anesthetic adjuvant in patients undergoing supratentorial tumor surgery. SETTING AND DESIGN: Prospective randomized control double blind study. SUBJECTS AND METHODS: In this study, we compared two groups with 25 patients in each group. Group C patients received saline infusion during surgery and 4 μg/kg of fentanyl intravenously (i.v.) at the induction and at pin head application. Group D patients received dexmedetomidine infusion during surgery at the rate of 0.4 μg/kg/h and 2 μg/kg of fentanyl i.v. at the induction and at pin head application STATISTICAL ANALYSES USED: Parametric data were analyzed using Student's t-test. The categorical data were studied using Chi-squared test or Fisher's test as appropriate. RESULTS: The vitals remained within 20% of baseline in both groups during the study period except at the time of extubation where the rise in heart rate was more than 20% in control group. The requirement of thiopentone for induction was significantly less in dexmedetomidine group. In dexmedetomidine group, less number of patients required intraoperative fentanyl (P < 0.05), and the time to rescue analgesic was also more in Group D (P < 0.05). CONCLUSION: Dexmedetomidine infusion started before surgery maintains hemodynamic stability intraoperatively and is effective in attenuating the cardiovascular responses to intubation, skull pin application, and extubation. It decreases the requirement of other anesthetic agents as well. |
format | Online Article Text |
id | pubmed-5490096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-54900962017-06-29 Dexmedetomidine as an Anesthetic Adjuvant in Intracranial Surgery Batra, Ankita Verma, Reetu Bhatia, V. K. Chandra, Girish Bhushan, Shashi Anesth Essays Res Original Article BACKGROUND: The basic principle of neuroanesthesia is to provide hemodynamic stability, provision of optimal operative conditions, maintenance of cerebral perfusion pressure, and cerebral oxygenation. AIM: This study was undertaken to see the effect of dexmedetomidine infusion on hemodynamics and its ability to act as an anesthetic adjuvant in patients undergoing supratentorial tumor surgery. SETTING AND DESIGN: Prospective randomized control double blind study. SUBJECTS AND METHODS: In this study, we compared two groups with 25 patients in each group. Group C patients received saline infusion during surgery and 4 μg/kg of fentanyl intravenously (i.v.) at the induction and at pin head application. Group D patients received dexmedetomidine infusion during surgery at the rate of 0.4 μg/kg/h and 2 μg/kg of fentanyl i.v. at the induction and at pin head application STATISTICAL ANALYSES USED: Parametric data were analyzed using Student's t-test. The categorical data were studied using Chi-squared test or Fisher's test as appropriate. RESULTS: The vitals remained within 20% of baseline in both groups during the study period except at the time of extubation where the rise in heart rate was more than 20% in control group. The requirement of thiopentone for induction was significantly less in dexmedetomidine group. In dexmedetomidine group, less number of patients required intraoperative fentanyl (P < 0.05), and the time to rescue analgesic was also more in Group D (P < 0.05). CONCLUSION: Dexmedetomidine infusion started before surgery maintains hemodynamic stability intraoperatively and is effective in attenuating the cardiovascular responses to intubation, skull pin application, and extubation. It decreases the requirement of other anesthetic agents as well. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5490096/ /pubmed/28663612 http://dx.doi.org/10.4103/0259-1162.194555 Text en Copyright: © 2016 Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Batra, Ankita Verma, Reetu Bhatia, V. K. Chandra, Girish Bhushan, Shashi Dexmedetomidine as an Anesthetic Adjuvant in Intracranial Surgery |
title | Dexmedetomidine as an Anesthetic Adjuvant in Intracranial Surgery |
title_full | Dexmedetomidine as an Anesthetic Adjuvant in Intracranial Surgery |
title_fullStr | Dexmedetomidine as an Anesthetic Adjuvant in Intracranial Surgery |
title_full_unstemmed | Dexmedetomidine as an Anesthetic Adjuvant in Intracranial Surgery |
title_short | Dexmedetomidine as an Anesthetic Adjuvant in Intracranial Surgery |
title_sort | dexmedetomidine as an anesthetic adjuvant in intracranial surgery |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490096/ https://www.ncbi.nlm.nih.gov/pubmed/28663612 http://dx.doi.org/10.4103/0259-1162.194555 |
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