The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

Elevated iron in the SNpc may play a key role in Parkinson’s disease (PD) neurodegeneration since drug candidates with high iron affinity rescue PD animal models, and one candidate, deferirpone, has shown efficacy recently in a phase two clinical trial. However, strong iron chelators may perturb ess...

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Detalles Bibliográficos
Autores principales: Finkelstein, David I., Billings, Jessica L., Adlard, Paul A., Ayton, Scott, Sedjahtera, Amelia, Masters, Colin L., Wilkins, Simon, Shackleford, David M., Charman, Susan A., Bal, Wojciech, Zawisza, Izabela A, Kurowska, Ewa, Gundlach, Andrew L., Ma, Sheri, Bush, Ashley I., Hare, Dominic J., Doble, Philip A., Crawford, Simon, Gautier, Elisabeth CL., Parsons, Jack, Huggins, Penny, Barnham, Kevin J., Cherny, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490188/
https://www.ncbi.nlm.nih.gov/pubmed/28659169
http://dx.doi.org/10.1186/s40478-017-0456-2

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