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Prevalence of sexual dimorphism in mammalian phenotypic traits
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490203/ https://www.ncbi.nlm.nih.gov/pubmed/28650954 http://dx.doi.org/10.1038/ncomms15475 |
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| author | Karp, Natasha A. Mason, Jeremy Beaudet, Arthur L. Benjamini, Yoav Bower, Lynette Braun, Robert E. Brown, Steve D.M. Chesler, Elissa J. Dickinson, Mary E. Flenniken, Ann M. Fuchs, Helmut Angelis, Martin Hrabe de Gao, Xiang Guo, Shiying Greenaway, Simon Heller, Ruth Herault, Yann Justice, Monica J. Kurbatova, Natalja Lelliott, Christopher J. Lloyd, K.C. Kent Mallon, Ann-Marie Mank, Judith E. Masuya, Hiroshi McKerlie, Colin Meehan, Terrence F. Mott, Richard F. Murray, Stephen A. Parkinson, Helen Ramirez-Solis, Ramiro Santos, Luis Seavitt, John R. Smedley, Damian Sorg, Tania Speak, Anneliese O. Steel, Karen P. Svenson, Karen L. Wakana, Shigeharu West, David Wells, Sara Westerberg, Henrik Yaacoby, Shay White, Jacqueline K. |
| author_facet | Karp, Natasha A. Mason, Jeremy Beaudet, Arthur L. Benjamini, Yoav Bower, Lynette Braun, Robert E. Brown, Steve D.M. Chesler, Elissa J. Dickinson, Mary E. Flenniken, Ann M. Fuchs, Helmut Angelis, Martin Hrabe de Gao, Xiang Guo, Shiying Greenaway, Simon Heller, Ruth Herault, Yann Justice, Monica J. Kurbatova, Natalja Lelliott, Christopher J. Lloyd, K.C. Kent Mallon, Ann-Marie Mank, Judith E. Masuya, Hiroshi McKerlie, Colin Meehan, Terrence F. Mott, Richard F. Murray, Stephen A. Parkinson, Helen Ramirez-Solis, Ramiro Santos, Luis Seavitt, John R. Smedley, Damian Sorg, Tania Speak, Anneliese O. Steel, Karen P. Svenson, Karen L. Wakana, Shigeharu West, David Wells, Sara Westerberg, Henrik Yaacoby, Shay White, Jacqueline K. |
| author_sort | Karp, Natasha A. |
| collection | PubMed |
| description | The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans. |
| format | Online Article Text |
| id | pubmed-5490203 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-54902032017-07-06 Prevalence of sexual dimorphism in mammalian phenotypic traits Karp, Natasha A. Mason, Jeremy Beaudet, Arthur L. Benjamini, Yoav Bower, Lynette Braun, Robert E. Brown, Steve D.M. Chesler, Elissa J. Dickinson, Mary E. Flenniken, Ann M. Fuchs, Helmut Angelis, Martin Hrabe de Gao, Xiang Guo, Shiying Greenaway, Simon Heller, Ruth Herault, Yann Justice, Monica J. Kurbatova, Natalja Lelliott, Christopher J. Lloyd, K.C. Kent Mallon, Ann-Marie Mank, Judith E. Masuya, Hiroshi McKerlie, Colin Meehan, Terrence F. Mott, Richard F. Murray, Stephen A. Parkinson, Helen Ramirez-Solis, Ramiro Santos, Luis Seavitt, John R. Smedley, Damian Sorg, Tania Speak, Anneliese O. Steel, Karen P. Svenson, Karen L. Wakana, Shigeharu West, David Wells, Sara Westerberg, Henrik Yaacoby, Shay White, Jacqueline K. Nat Commun Article The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans. Nature Publishing Group 2017-06-26 /pmc/articles/PMC5490203/ /pubmed/28650954 http://dx.doi.org/10.1038/ncomms15475 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Karp, Natasha A. Mason, Jeremy Beaudet, Arthur L. Benjamini, Yoav Bower, Lynette Braun, Robert E. Brown, Steve D.M. Chesler, Elissa J. Dickinson, Mary E. Flenniken, Ann M. Fuchs, Helmut Angelis, Martin Hrabe de Gao, Xiang Guo, Shiying Greenaway, Simon Heller, Ruth Herault, Yann Justice, Monica J. Kurbatova, Natalja Lelliott, Christopher J. Lloyd, K.C. Kent Mallon, Ann-Marie Mank, Judith E. Masuya, Hiroshi McKerlie, Colin Meehan, Terrence F. Mott, Richard F. Murray, Stephen A. Parkinson, Helen Ramirez-Solis, Ramiro Santos, Luis Seavitt, John R. Smedley, Damian Sorg, Tania Speak, Anneliese O. Steel, Karen P. Svenson, Karen L. Wakana, Shigeharu West, David Wells, Sara Westerberg, Henrik Yaacoby, Shay White, Jacqueline K. Prevalence of sexual dimorphism in mammalian phenotypic traits |
| title | Prevalence of sexual dimorphism in mammalian phenotypic traits |
| title_full | Prevalence of sexual dimorphism in mammalian phenotypic traits |
| title_fullStr | Prevalence of sexual dimorphism in mammalian phenotypic traits |
| title_full_unstemmed | Prevalence of sexual dimorphism in mammalian phenotypic traits |
| title_short | Prevalence of sexual dimorphism in mammalian phenotypic traits |
| title_sort | prevalence of sexual dimorphism in mammalian phenotypic traits |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490203/ https://www.ncbi.nlm.nih.gov/pubmed/28650954 http://dx.doi.org/10.1038/ncomms15475 |
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