Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient

BACKGROUND AND PURPOSE: Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This disorder results in recurrent life-threatening bacterial and fungal infections. Aspergillus species are the most common fungal infecti...

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Autores principales: Mamishi, S, Zomorodian, K, Saadat, F, Jalali, SZ, Geramishoar, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Medical Mycology 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490289/
https://www.ncbi.nlm.nih.gov/pubmed/28681028
http://dx.doi.org/10.18869/acadpub.cmm.2.3.37
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author Mamishi, S
Zomorodian, K
Saadat, F
Jalali, SZ
Geramishoar, M
author_facet Mamishi, S
Zomorodian, K
Saadat, F
Jalali, SZ
Geramishoar, M
author_sort Mamishi, S
collection PubMed
description BACKGROUND AND PURPOSE: Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This disorder results in recurrent life-threatening bacterial and fungal infections. Aspergillus species are the most common fungal infections in these patients. CASE REPORT: Herein, we present a case of fungal infection in a girl with CGD. We confirmed aspergillosis through the positive microscopic and macroscopic examinations, as well as radiology results. Invasive aspergillosis in this patient with pneumonia, lung abscess, and osteomyelitis of the ribs was not initially treated with amphotericin B (Am B) and recombinant interferon-gamma. CONCLUSION: Among infectious diseases, fungal infections, in particular aspergillosis, remain a serious problem in CGD patients. Considering poor clinical response and deficient immune system, rapid diagnosis of fungal infection and optimizing the treatment of these patients are recommended.
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spelling pubmed-54902892017-07-05 Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient Mamishi, S Zomorodian, K Saadat, F Jalali, SZ Geramishoar, M Curr Med Mycol Case Report BACKGROUND AND PURPOSE: Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This disorder results in recurrent life-threatening bacterial and fungal infections. Aspergillus species are the most common fungal infections in these patients. CASE REPORT: Herein, we present a case of fungal infection in a girl with CGD. We confirmed aspergillosis through the positive microscopic and macroscopic examinations, as well as radiology results. Invasive aspergillosis in this patient with pneumonia, lung abscess, and osteomyelitis of the ribs was not initially treated with amphotericin B (Am B) and recombinant interferon-gamma. CONCLUSION: Among infectious diseases, fungal infections, in particular aspergillosis, remain a serious problem in CGD patients. Considering poor clinical response and deficient immune system, rapid diagnosis of fungal infection and optimizing the treatment of these patients are recommended. Iranian Society of Medical Mycology 2016-09 /pmc/articles/PMC5490289/ /pubmed/28681028 http://dx.doi.org/10.18869/acadpub.cmm.2.3.37 Text en Copyright© 2016, Published by Mazandaran University of Medical Sciences on behalf of Iranian Society of Medical Mycology and Invasive Fungi Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International License (http://creativecommons.org/licenses/bync/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Case Report
Mamishi, S
Zomorodian, K
Saadat, F
Jalali, SZ
Geramishoar, M
Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient
title Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient
title_full Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient
title_fullStr Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient
title_full_unstemmed Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient
title_short Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient
title_sort osteomyelitis and lung abscess due to aspergillus fumigatus in a chronic granulomatous disease patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490289/
https://www.ncbi.nlm.nih.gov/pubmed/28681028
http://dx.doi.org/10.18869/acadpub.cmm.2.3.37
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