Discovery of a novel ligand that modulates the protein–protein interactions of the AAA+ superfamily oncoprotein reptin

Developing approaches to discover protein–protein interactions (PPIs) remains a fundamental challenge. A chemical biology platform is applied here to identify novel PPIs for the AAA+ superfamily oncoprotein reptin. An in silico screen coupled with chemical optimization provided Liddean, a nucleotide...

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Detalles Bibliográficos
Autores principales: Healy, Alan R., Houston, Douglas R., Remnant, Lucy, Huart, Anne-Sophie, Brychtova, Veronika, Maslon, Magda M., Meers, Olivia, Muller, Petr, Krejci, Adam, Blackburn, Elizabeth A., Vojtesek, Borek, Hernychova, Lenka, Walkinshaw, Malcolm D., Westwood, Nicholas J., Hupp, Ted R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490336/
https://www.ncbi.nlm.nih.gov/pubmed/28706685
http://dx.doi.org/10.1039/c4sc03885a

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