HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?

The Tat protein of HIV-1 is a powerful activator of viral gene expression. Besides this essential function at the HIV-1 promoter, the protein also exerts a remarkable number of other biological activities, among which the induction of cellular apoptosis. Two papers now published in Retrovirology pro...

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Detalles Bibliográficos
Autor principal: Giacca, Mauro
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549042/
https://www.ncbi.nlm.nih.gov/pubmed/15698476
http://dx.doi.org/10.1186/1742-4690-2-7
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author Giacca, Mauro
author_facet Giacca, Mauro
author_sort Giacca, Mauro
collection PubMed
description The Tat protein of HIV-1 is a powerful activator of viral gene expression. Besides this essential function at the HIV-1 promoter, the protein also exerts a remarkable number of other biological activities, among which the induction of cellular apoptosis. Two papers now published in Retrovirology provide possible molecular mechanisms for the pro-apoptotic effect of Tat, which involve the cell's microtubular network and the mitochondrial pathway of apoptosis.
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spelling pubmed-5490422005-02-18 HIV-1 Tat, apoptosis and the mitochondria: a tubulin link? Giacca, Mauro Retrovirology Commentary The Tat protein of HIV-1 is a powerful activator of viral gene expression. Besides this essential function at the HIV-1 promoter, the protein also exerts a remarkable number of other biological activities, among which the induction of cellular apoptosis. Two papers now published in Retrovirology provide possible molecular mechanisms for the pro-apoptotic effect of Tat, which involve the cell's microtubular network and the mitochondrial pathway of apoptosis. BioMed Central 2005-02-07 /pmc/articles/PMC549042/ /pubmed/15698476 http://dx.doi.org/10.1186/1742-4690-2-7 Text en Copyright © 2005 Giacca; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Giacca, Mauro
HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?
title HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?
title_full HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?
title_fullStr HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?
title_full_unstemmed HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?
title_short HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?
title_sort hiv-1 tat, apoptosis and the mitochondria: a tubulin link?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549042/
https://www.ncbi.nlm.nih.gov/pubmed/15698476
http://dx.doi.org/10.1186/1742-4690-2-7
work_keys_str_mv AT giaccamauro hiv1tatapoptosisandthemitochondriaatubulinlink

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