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Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety

Colibactin represents a structurally undefined class of bacterial genotoxin inducing DNA damage and genomic instability in mammalian cells, thus promoting tumour development and exacerbating lymphopenia in animal models. The colibactin biosynthetic gene cluster (clb) has been known for ten years and...

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Detalles Bibliográficos
Autores principales: Bian, Xiaoying, Plaza, Alberto, Zhang, Youming, Müller, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490422/
https://www.ncbi.nlm.nih.gov/pubmed/28706687
http://dx.doi.org/10.1039/c5sc00101c