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Epithelial spindle orientation diversities and uncertainties: recent developments and lingering questions
Mitotic spindle orientation is a conserved, dynamic, and highly complex process that plays a key role in dictating the cleavage plane, fate, and positioning of cells within a tissue, therefore laying the blueprint for tissue structure and function. While the spindle-positioning pathway has been exte...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490480/ https://www.ncbi.nlm.nih.gov/pubmed/28713562 http://dx.doi.org/10.12688/f1000research.11370.1 |
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author | Seldin, Lindsey Macara, Ian |
author_facet | Seldin, Lindsey Macara, Ian |
author_sort | Seldin, Lindsey |
collection | PubMed |
description | Mitotic spindle orientation is a conserved, dynamic, and highly complex process that plays a key role in dictating the cleavage plane, fate, and positioning of cells within a tissue, therefore laying the blueprint for tissue structure and function. While the spindle-positioning pathway has been extensively studied in lower-model organisms, research over the past several years has highlighted its relevance to mammalian epithelial tissues. Although we continue to gain critical insights into the mechanisms underlying spindle positioning, many uncertainties persist. In this commentary, we will review the protein interactions that modulate spindle orientation and we will present important recent findings that underscore epithelial tissue-specific requirements and variations in this important pathway, as well as its potential relevance to cancer. |
format | Online Article Text |
id | pubmed-5490480 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-54904802017-07-13 Epithelial spindle orientation diversities and uncertainties: recent developments and lingering questions Seldin, Lindsey Macara, Ian F1000Res Review Mitotic spindle orientation is a conserved, dynamic, and highly complex process that plays a key role in dictating the cleavage plane, fate, and positioning of cells within a tissue, therefore laying the blueprint for tissue structure and function. While the spindle-positioning pathway has been extensively studied in lower-model organisms, research over the past several years has highlighted its relevance to mammalian epithelial tissues. Although we continue to gain critical insights into the mechanisms underlying spindle positioning, many uncertainties persist. In this commentary, we will review the protein interactions that modulate spindle orientation and we will present important recent findings that underscore epithelial tissue-specific requirements and variations in this important pathway, as well as its potential relevance to cancer. F1000Research 2017-06-23 /pmc/articles/PMC5490480/ /pubmed/28713562 http://dx.doi.org/10.12688/f1000research.11370.1 Text en Copyright: © 2017 Seldin L and Macara I http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Seldin, Lindsey Macara, Ian Epithelial spindle orientation diversities and uncertainties: recent developments and lingering questions |
title | Epithelial spindle orientation diversities and uncertainties: recent developments and lingering questions |
title_full | Epithelial spindle orientation diversities and uncertainties: recent developments and lingering questions |
title_fullStr | Epithelial spindle orientation diversities and uncertainties: recent developments and lingering questions |
title_full_unstemmed | Epithelial spindle orientation diversities and uncertainties: recent developments and lingering questions |
title_short | Epithelial spindle orientation diversities and uncertainties: recent developments and lingering questions |
title_sort | epithelial spindle orientation diversities and uncertainties: recent developments and lingering questions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490480/ https://www.ncbi.nlm.nih.gov/pubmed/28713562 http://dx.doi.org/10.12688/f1000research.11370.1 |
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