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Selected Risk Nutritional Factors for Chemotherapy-Induced Polyneuropathy

The present study seeks to identify the nutritional risk factors involved in the development of neuropathies induced by chemotherapeutic treatments. Unlike the gastrointestinal or hematological adverse effects of chemotherapy there is no protective treatment strategy for polyneuropathy. The aim of t...

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Autores principales: Grim, Jiri, Ticha, Alena, Hyspler, Radomir, Valis, Martin, Zadak, Zdenek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490514/
https://www.ncbi.nlm.nih.gov/pubmed/28587059
http://dx.doi.org/10.3390/nu9060535
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author Grim, Jiri
Ticha, Alena
Hyspler, Radomir
Valis, Martin
Zadak, Zdenek
author_facet Grim, Jiri
Ticha, Alena
Hyspler, Radomir
Valis, Martin
Zadak, Zdenek
author_sort Grim, Jiri
collection PubMed
description The present study seeks to identify the nutritional risk factors involved in the development of neuropathies induced by chemotherapeutic treatments. Unlike the gastrointestinal or hematological adverse effects of chemotherapy there is no protective treatment strategy for polyneuropathy. The aim of this study was to find possible deficiencies in nutritional factors, which can be used for supplementation in the future for prevention of chemotherapy-induced neuropathy development. We analyzed 70 patients undergoing paclitaxel chemotherapy and evaluated the risk factors involved in chemotherapy-induced peripheral neuropathy (CIPN). Several risk factors were considered in the development of CIPN, including deficiency of vitamin B1, B6, and D and fatty acids. The occurrence of CIPN complication in 60% cases was observed. We found significant differences in vitamin D and saturated fatty acid concentration. Vitamin D levels in the group without CIPN were estimated to be 38.2 (24.95, 47.63) nmol/L, whereas in the group with CIPN it was determined to be 25.6 (19.7, 32.55) nmol/L, p = 0.008. The level of total saturated fatty acids in the group without CIPN was of 32.613 Area % (31.322; 36.262), whereas in the group with CIPN it was of 34.209 Area % (32.86; 39.386), p = 0.01. The obtained results suggest a diet lower in saturated fatty acid content during chemotherapy. The most significant finding was that supplementation of vitamin D before chemotherapy could be an efficient neuroprotective in CIPN prophylaxis, as significantly lower levels 25OH derivative of vitamin D were observed in the CIPN group throughout the study period.
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spelling pubmed-54905142017-07-03 Selected Risk Nutritional Factors for Chemotherapy-Induced Polyneuropathy Grim, Jiri Ticha, Alena Hyspler, Radomir Valis, Martin Zadak, Zdenek Nutrients Article The present study seeks to identify the nutritional risk factors involved in the development of neuropathies induced by chemotherapeutic treatments. Unlike the gastrointestinal or hematological adverse effects of chemotherapy there is no protective treatment strategy for polyneuropathy. The aim of this study was to find possible deficiencies in nutritional factors, which can be used for supplementation in the future for prevention of chemotherapy-induced neuropathy development. We analyzed 70 patients undergoing paclitaxel chemotherapy and evaluated the risk factors involved in chemotherapy-induced peripheral neuropathy (CIPN). Several risk factors were considered in the development of CIPN, including deficiency of vitamin B1, B6, and D and fatty acids. The occurrence of CIPN complication in 60% cases was observed. We found significant differences in vitamin D and saturated fatty acid concentration. Vitamin D levels in the group without CIPN were estimated to be 38.2 (24.95, 47.63) nmol/L, whereas in the group with CIPN it was determined to be 25.6 (19.7, 32.55) nmol/L, p = 0.008. The level of total saturated fatty acids in the group without CIPN was of 32.613 Area % (31.322; 36.262), whereas in the group with CIPN it was of 34.209 Area % (32.86; 39.386), p = 0.01. The obtained results suggest a diet lower in saturated fatty acid content during chemotherapy. The most significant finding was that supplementation of vitamin D before chemotherapy could be an efficient neuroprotective in CIPN prophylaxis, as significantly lower levels 25OH derivative of vitamin D were observed in the CIPN group throughout the study period. MDPI 2017-05-25 /pmc/articles/PMC5490514/ /pubmed/28587059 http://dx.doi.org/10.3390/nu9060535 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grim, Jiri
Ticha, Alena
Hyspler, Radomir
Valis, Martin
Zadak, Zdenek
Selected Risk Nutritional Factors for Chemotherapy-Induced Polyneuropathy
title Selected Risk Nutritional Factors for Chemotherapy-Induced Polyneuropathy
title_full Selected Risk Nutritional Factors for Chemotherapy-Induced Polyneuropathy
title_fullStr Selected Risk Nutritional Factors for Chemotherapy-Induced Polyneuropathy
title_full_unstemmed Selected Risk Nutritional Factors for Chemotherapy-Induced Polyneuropathy
title_short Selected Risk Nutritional Factors for Chemotherapy-Induced Polyneuropathy
title_sort selected risk nutritional factors for chemotherapy-induced polyneuropathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490514/
https://www.ncbi.nlm.nih.gov/pubmed/28587059
http://dx.doi.org/10.3390/nu9060535
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