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Randomized Controlled Trial of DHA Supplementation during Pregnancy: Child Adiposity Outcomes

Investigating safe and effective interventions in pregnancy that lower offspring adiposity is important given the burden of obesity and subsequent metabolic derangements. Our objective was to determine if docosahexaenoic acid (DHA) given during pregnancy to obese mothers results in lower offspring a...

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Autores principales: Foster, Byron A., Escaname, Elia, Powell, Theresa L., Larsen, Benjamin, Siddiqui, Sartaj K., Menchaca, John, Aquino, Christian, Ramamurthy, Rajam, Hale, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490545/
https://www.ncbi.nlm.nih.gov/pubmed/28574453
http://dx.doi.org/10.3390/nu9060566
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author Foster, Byron A.
Escaname, Elia
Powell, Theresa L.
Larsen, Benjamin
Siddiqui, Sartaj K.
Menchaca, John
Aquino, Christian
Ramamurthy, Rajam
Hale, Daniel E.
author_facet Foster, Byron A.
Escaname, Elia
Powell, Theresa L.
Larsen, Benjamin
Siddiqui, Sartaj K.
Menchaca, John
Aquino, Christian
Ramamurthy, Rajam
Hale, Daniel E.
author_sort Foster, Byron A.
collection PubMed
description Investigating safe and effective interventions in pregnancy that lower offspring adiposity is important given the burden of obesity and subsequent metabolic derangements. Our objective was to determine if docosahexaenoic acid (DHA) given during pregnancy to obese mothers results in lower offspring adiposity. This study was a long-term follow-up of a randomized trial of mothers with gestational diabetes or obesity who were randomized to receive DHA supplementation at 800 mg/day or placebo (corn/soy oil) starting at 25–29 weeks gestation. Anthropometric measures were collected at birth and maternal erythrocyte DHA and arachidonic (AA) levels were measured at 26 and 36 weeks gestation. At two- and four-year follow-up time points, offspring adiposity measures along with a diet recall were assessed. A significant increase in erythrocyte DHA levels was observed at 36 weeks gestation in the supplemented group (p < 0.001). While no significant differences by measures of adiposity were noted at birth, two or four years by randomization group, duration of breastfeeding (p < 0.001), and DHA level at 36 weeks (p = 0.002) were associated with body mass index z-score. Our data suggest that DHA supplementation during pregnancy in obese mothers may have long-lasting effects on offspring measures of adiposity.
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spelling pubmed-54905452017-07-03 Randomized Controlled Trial of DHA Supplementation during Pregnancy: Child Adiposity Outcomes Foster, Byron A. Escaname, Elia Powell, Theresa L. Larsen, Benjamin Siddiqui, Sartaj K. Menchaca, John Aquino, Christian Ramamurthy, Rajam Hale, Daniel E. Nutrients Article Investigating safe and effective interventions in pregnancy that lower offspring adiposity is important given the burden of obesity and subsequent metabolic derangements. Our objective was to determine if docosahexaenoic acid (DHA) given during pregnancy to obese mothers results in lower offspring adiposity. This study was a long-term follow-up of a randomized trial of mothers with gestational diabetes or obesity who were randomized to receive DHA supplementation at 800 mg/day or placebo (corn/soy oil) starting at 25–29 weeks gestation. Anthropometric measures were collected at birth and maternal erythrocyte DHA and arachidonic (AA) levels were measured at 26 and 36 weeks gestation. At two- and four-year follow-up time points, offspring adiposity measures along with a diet recall were assessed. A significant increase in erythrocyte DHA levels was observed at 36 weeks gestation in the supplemented group (p < 0.001). While no significant differences by measures of adiposity were noted at birth, two or four years by randomization group, duration of breastfeeding (p < 0.001), and DHA level at 36 weeks (p = 0.002) were associated with body mass index z-score. Our data suggest that DHA supplementation during pregnancy in obese mothers may have long-lasting effects on offspring measures of adiposity. MDPI 2017-06-02 /pmc/articles/PMC5490545/ /pubmed/28574453 http://dx.doi.org/10.3390/nu9060566 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Foster, Byron A.
Escaname, Elia
Powell, Theresa L.
Larsen, Benjamin
Siddiqui, Sartaj K.
Menchaca, John
Aquino, Christian
Ramamurthy, Rajam
Hale, Daniel E.
Randomized Controlled Trial of DHA Supplementation during Pregnancy: Child Adiposity Outcomes
title Randomized Controlled Trial of DHA Supplementation during Pregnancy: Child Adiposity Outcomes
title_full Randomized Controlled Trial of DHA Supplementation during Pregnancy: Child Adiposity Outcomes
title_fullStr Randomized Controlled Trial of DHA Supplementation during Pregnancy: Child Adiposity Outcomes
title_full_unstemmed Randomized Controlled Trial of DHA Supplementation during Pregnancy: Child Adiposity Outcomes
title_short Randomized Controlled Trial of DHA Supplementation during Pregnancy: Child Adiposity Outcomes
title_sort randomized controlled trial of dha supplementation during pregnancy: child adiposity outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490545/
https://www.ncbi.nlm.nih.gov/pubmed/28574453
http://dx.doi.org/10.3390/nu9060566
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