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Microbiota and Probiotics in Health and HIV Infection

Microbiota play a key role in various body functions, as well as in physiological, metabolic, and immunological processes, through different mechanisms such as the regulation of the development and/or functions of different types of immune cells in the intestines. Evidence indicates that alteration...

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Autores principales: D’Angelo, Chiara, Reale, Marcella, Costantini, Erica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490594/
https://www.ncbi.nlm.nih.gov/pubmed/28621726
http://dx.doi.org/10.3390/nu9060615
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author D’Angelo, Chiara
Reale, Marcella
Costantini, Erica
author_facet D’Angelo, Chiara
Reale, Marcella
Costantini, Erica
author_sort D’Angelo, Chiara
collection PubMed
description Microbiota play a key role in various body functions, as well as in physiological, metabolic, and immunological processes, through different mechanisms such as the regulation of the development and/or functions of different types of immune cells in the intestines. Evidence indicates that alteration in the gut microbiota can influence infectious and non-infectious diseases. Bacteria that reside on the mucosal surface or within the mucus layer interact with the host immune system, thus, a healthy gut microbiota is essential for the development of mucosal immunity. In patients with human immunodeficiency virus (HIV), including those who control their disease with antiretroviral drugs (ART), the gut microbiome is very different than the microbiome of those not infected with HIV. Recent data suggests that, for these patients, dysbiosis may lead to a breakdown in the gut’s immunologic activity, causing systemic bacteria diffusion and inflammation. Since in HIV-infected patients in this state, including those in ART therapy, the treatment of gastrointestinal tract disorders is frustrating, many studies are in progress to investigate the ability of probiotics to modulate epithelial barrier functions, microbiota composition, and microbial translocation. This mini-review analyzed the use of probiotics to prevent and attenuate several gastrointestinal manifestations and to improve gut-associated lymphoid tissue (GALT) immunity in HIV infection.
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spelling pubmed-54905942017-07-03 Microbiota and Probiotics in Health and HIV Infection D’Angelo, Chiara Reale, Marcella Costantini, Erica Nutrients Review Microbiota play a key role in various body functions, as well as in physiological, metabolic, and immunological processes, through different mechanisms such as the regulation of the development and/or functions of different types of immune cells in the intestines. Evidence indicates that alteration in the gut microbiota can influence infectious and non-infectious diseases. Bacteria that reside on the mucosal surface or within the mucus layer interact with the host immune system, thus, a healthy gut microbiota is essential for the development of mucosal immunity. In patients with human immunodeficiency virus (HIV), including those who control their disease with antiretroviral drugs (ART), the gut microbiome is very different than the microbiome of those not infected with HIV. Recent data suggests that, for these patients, dysbiosis may lead to a breakdown in the gut’s immunologic activity, causing systemic bacteria diffusion and inflammation. Since in HIV-infected patients in this state, including those in ART therapy, the treatment of gastrointestinal tract disorders is frustrating, many studies are in progress to investigate the ability of probiotics to modulate epithelial barrier functions, microbiota composition, and microbial translocation. This mini-review analyzed the use of probiotics to prevent and attenuate several gastrointestinal manifestations and to improve gut-associated lymphoid tissue (GALT) immunity in HIV infection. MDPI 2017-06-16 /pmc/articles/PMC5490594/ /pubmed/28621726 http://dx.doi.org/10.3390/nu9060615 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
D’Angelo, Chiara
Reale, Marcella
Costantini, Erica
Microbiota and Probiotics in Health and HIV Infection
title Microbiota and Probiotics in Health and HIV Infection
title_full Microbiota and Probiotics in Health and HIV Infection
title_fullStr Microbiota and Probiotics in Health and HIV Infection
title_full_unstemmed Microbiota and Probiotics in Health and HIV Infection
title_short Microbiota and Probiotics in Health and HIV Infection
title_sort microbiota and probiotics in health and hiv infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490594/
https://www.ncbi.nlm.nih.gov/pubmed/28621726
http://dx.doi.org/10.3390/nu9060615
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