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Monoclonal antibodies expression improvement in CHO cells by PiggyBac transposition regarding vectors ratios and design
Establishing stable Chinese Hamster Ovary (CHO) cells producing monoclonal antibodies (mAbs) usually pass through the random integration of vectors to the cell genome, which is sensitive to gene silencing. One approach to overcome this issue is to target a highly transcribed region in the genome. Tr...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491063/ https://www.ncbi.nlm.nih.gov/pubmed/28662065 http://dx.doi.org/10.1371/journal.pone.0179902 |