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A novel monoclonal antibody against the N-terminus of Aβ(1-42) reduces plaques and improves cognition in a mouse model of Alzheimer’s disease

Senile plaques consisting of Amyloid-beta (Aβ) peptides, in particular Aβ(1–42), are the hallmark of Alzheimer’s disease (AD) and have been the primary therapeutic targets. Passive immunotherapy with monoclonal antibodies (mAbs) has shown initial success in mouse models of AD. However, the existing...

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Detalles Bibliográficos
Autores principales:	Xing, Hai-Yan, Li, Bin, Peng, Dan, Wang, Chun-Yan, Wang, Guan-Ying, Li, Pan, Le, Ying-Ying, Wang, Ji-Ming, Ye, George, Chen, Jian-Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491112/ https://www.ncbi.nlm.nih.gov/pubmed/28662102 http://dx.doi.org/10.1371/journal.pone.0180076

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