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Preliminary dosimetric study on feasibility of multi-beam boron neutron capture therapy in patients with diffuse intrinsic pontine glioma without craniotomy

Diffuse intrinsic pontine glioma is a very frustrating disease. Since the tumor infiltrates the brain stem, surgical removal is often impossible. For conventional radiotherapy, the dose constraint of the brain stem impedes attempts at further dose escalation. Boron neutron capture therapy (BNCT), a...

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Autores principales: Lee, Jia-Cheng, Chuang, Keh-Shih, Chen, Yi-Wei, Hsu, Fang-Yuh, Chou, Fong-In, Yen, Sang-Hue, Wu, Yuan-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491244/
https://www.ncbi.nlm.nih.gov/pubmed/28662135
http://dx.doi.org/10.1371/journal.pone.0180461
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author Lee, Jia-Cheng
Chuang, Keh-Shih
Chen, Yi-Wei
Hsu, Fang-Yuh
Chou, Fong-In
Yen, Sang-Hue
Wu, Yuan-Hung
author_facet Lee, Jia-Cheng
Chuang, Keh-Shih
Chen, Yi-Wei
Hsu, Fang-Yuh
Chou, Fong-In
Yen, Sang-Hue
Wu, Yuan-Hung
author_sort Lee, Jia-Cheng
collection PubMed
description Diffuse intrinsic pontine glioma is a very frustrating disease. Since the tumor infiltrates the brain stem, surgical removal is often impossible. For conventional radiotherapy, the dose constraint of the brain stem impedes attempts at further dose escalation. Boron neutron capture therapy (BNCT), a targeted radiotherapy, carries the potential to selectively irradiate tumors with an adequate dose while sparing adjacent normal tissue. In this study, 12 consecutive patients treated with conventional radiotherapy in our institute were reviewed to evaluate the feasibility of BNCT. NCTPlan Ver. 1.1.44 was used for dose calculations. Compared with two and three fields, the average maximal dose to the normal brain may be lowered to 7.35 ± 0.72 Gy-Eq by four-field irradiation. The mean ratio of minimal dose to clinical target volume and maximal dose to normal tissue was 2.41 ± 0.26 by four-field irradiation. A therapeutic benefit may be expected with multi-field boron neutron capture therapy to treat diffuse intrinsic pontine glioma without craniotomy, while the maximal dose to the normal brain would be minimized by using the four-field setting.
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spelling pubmed-54912442017-07-18 Preliminary dosimetric study on feasibility of multi-beam boron neutron capture therapy in patients with diffuse intrinsic pontine glioma without craniotomy Lee, Jia-Cheng Chuang, Keh-Shih Chen, Yi-Wei Hsu, Fang-Yuh Chou, Fong-In Yen, Sang-Hue Wu, Yuan-Hung PLoS One Research Article Diffuse intrinsic pontine glioma is a very frustrating disease. Since the tumor infiltrates the brain stem, surgical removal is often impossible. For conventional radiotherapy, the dose constraint of the brain stem impedes attempts at further dose escalation. Boron neutron capture therapy (BNCT), a targeted radiotherapy, carries the potential to selectively irradiate tumors with an adequate dose while sparing adjacent normal tissue. In this study, 12 consecutive patients treated with conventional radiotherapy in our institute were reviewed to evaluate the feasibility of BNCT. NCTPlan Ver. 1.1.44 was used for dose calculations. Compared with two and three fields, the average maximal dose to the normal brain may be lowered to 7.35 ± 0.72 Gy-Eq by four-field irradiation. The mean ratio of minimal dose to clinical target volume and maximal dose to normal tissue was 2.41 ± 0.26 by four-field irradiation. A therapeutic benefit may be expected with multi-field boron neutron capture therapy to treat diffuse intrinsic pontine glioma without craniotomy, while the maximal dose to the normal brain would be minimized by using the four-field setting. Public Library of Science 2017-06-29 /pmc/articles/PMC5491244/ /pubmed/28662135 http://dx.doi.org/10.1371/journal.pone.0180461 Text en © 2017 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lee, Jia-Cheng
Chuang, Keh-Shih
Chen, Yi-Wei
Hsu, Fang-Yuh
Chou, Fong-In
Yen, Sang-Hue
Wu, Yuan-Hung
Preliminary dosimetric study on feasibility of multi-beam boron neutron capture therapy in patients with diffuse intrinsic pontine glioma without craniotomy
title Preliminary dosimetric study on feasibility of multi-beam boron neutron capture therapy in patients with diffuse intrinsic pontine glioma without craniotomy
title_full Preliminary dosimetric study on feasibility of multi-beam boron neutron capture therapy in patients with diffuse intrinsic pontine glioma without craniotomy
title_fullStr Preliminary dosimetric study on feasibility of multi-beam boron neutron capture therapy in patients with diffuse intrinsic pontine glioma without craniotomy
title_full_unstemmed Preliminary dosimetric study on feasibility of multi-beam boron neutron capture therapy in patients with diffuse intrinsic pontine glioma without craniotomy
title_short Preliminary dosimetric study on feasibility of multi-beam boron neutron capture therapy in patients with diffuse intrinsic pontine glioma without craniotomy
title_sort preliminary dosimetric study on feasibility of multi-beam boron neutron capture therapy in patients with diffuse intrinsic pontine glioma without craniotomy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491244/
https://www.ncbi.nlm.nih.gov/pubmed/28662135
http://dx.doi.org/10.1371/journal.pone.0180461
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