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The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes
5’-3’ decay is the major mRNA decay pathway in many eukaryotes, including trypanosomes. After deadenylation, mRNAs are decapped by the nudix hydrolase DCP2 of the decapping complex and finally degraded by the 5’-3’ exoribonuclease. Uniquely, trypanosomes lack homologues to all subunits of the decapp...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491325/ https://www.ncbi.nlm.nih.gov/pubmed/28628654 http://dx.doi.org/10.1371/journal.ppat.1006456 |