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The Coordinated Action of Calcineurin and Cathepsin D Protects Against α-Synuclein Toxicity
The degeneration of dopaminergic neurons during Parkinson’s disease (PD) is intimately linked to malfunction of α-synuclein (αSyn), the main component of the proteinaceous intracellular inclusions characteristic for this pathology. The cytotoxicity of αSyn has been attributed to disturbances in seve...
Autores principales: | Aufschnaiter, Andreas, Habernig, Lukas, Kohler, Verena, Diessl, Jutta, Carmona-Gutierrez, Didac, Eisenberg, Tobias, Keller, Walter, Büttner, Sabrina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491553/ https://www.ncbi.nlm.nih.gov/pubmed/28713240 http://dx.doi.org/10.3389/fnmol.2017.00207 |
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