Cargando…

Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target

Mitochondria are the key source of ATP that fuels cellular functions, and they are also central in cellular signaling, cell division and apoptosis. Dysfunction of mitochondria has been implicated in a wide range of diseases, including neurodegenerative and cardiac diseases, and various types of canc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Camara, Amadou K. S., Zhou, YiFan, Wen, Po-Chao, Tajkhorshid, Emad, Kwok, Wai-Meng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491678/ https://www.ncbi.nlm.nih.gov/pubmed/28713289 http://dx.doi.org/10.3389/fphys.2017.00460

Ejemplares similares

Editorial: Mitochondrial Exchangers and Transporters in Cell Survival and Death
por: Kwok, Wai-Meng, et al.
Publicado: (2021)

Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
por: Haloi, Nandan, et al.
Publicado: (2021)

Knockout of VDAC1 in H9c2 Cells Promotes Oxidative Stress-Induced Cell Apoptosis through Decreased Mitochondrial Hexokinase II Binding and Enhanced Glycolytic Stress
por: Yang, Meiying, et al.
Publicado: (2020)

Markov chain Monte Carlo based analysis of post-translationally modified VDAC gating kinetics
por: Tewari, Shivendra G., et al.
Publicado: (2015)

LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling
por: Natarajan, Gayathri K., et al.
Publicado: (2021)

VDAC Modulation of Cancer Metabolism: Advances and Therapeutic Challenges
por: Heslop, Kareem A., et al.
Publicado: (2021)

A Calcium Guard in the Outer Membrane: Is VDAC a Regulated Gatekeeper of Mitochondrial Calcium Uptake?
por: Sander, Paulina, et al.
Publicado: (2021)

Targeting the Multiple Physiologic Roles of VDAC With Steroids and Hydrophobic Drugs
por: Rostovtseva, Tatiana K., et al.
Publicado: (2020)

Tubulin-VDAC Interaction: Molecular Basis for Mitochondrial Dysfunction in Chemotherapy-Induced Peripheral Neuropathy
por: Rovini, Amandine
Publicado: (2019)

VDAC Genes Expression and Regulation in Mammals
por: Zinghirino, Federica, et al.
Publicado: (2021)

Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases
por: Escobar-Henriques, Mafalda, et al.
Publicado: (2019)

Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury
por: Agarwal, Bhawana, et al.
Publicado: (2014)

Editorial: VDAC Structure and Function: An Up-to-Date View
por: De Pinto, Vito, et al.
Publicado: (2022)

VDACs: An Outlook on Biochemical Regulation and Function in Animal and Plant Systems
por: Ravi, Barkha, et al.
Publicado: (2021)

Total Matrix Ca(2+) Modulates Ca(2+) Efflux via the Ca(2+)/H(+) Exchanger in Cardiac Mitochondria
por: Natarajan, Gayathri K., et al.
Publicado: (2020)

Mitochondrial Approaches to Protect Against Cardiac Ischemia and Reperfusion Injury
por: Camara, Amadou K. S., et al.
Publicado: (2011)

Targeting the Mitochondrial Protein VDAC1 as a Potential Therapeutic Strategy in ALS
por: Shteinfer-Kuzmine, Anna, et al.
Publicado: (2022)

Mitochondria: hubs of cellular signaling, energetics and redox balance. A rich, vibrant, and diverse landscape of mitochondrial research
por: Aon, Miguel A., et al.
Publicado: (2015)

Slow Ca(2+) Efflux by Ca(2+)/H(+) Exchange in Cardiac Mitochondria Is Modulated by Ca(2+) Re-uptake via MCU, Extra-Mitochondrial pH, and H(+) Pumping by F(O)F(1)-ATPase
por: Haumann, Johan, et al.
Publicado: (2019)

A C-Terminally Truncated Variant of Neurospora crassa VDAC Assembles Into a Partially Functional Form in the Mitochondrial Outer Membrane and Forms Multimers in vitro
por: Ferens, Fraser G., et al.
Publicado: (2021)

Adverse Effects of Metformin From Diabetes to COVID-19, Cancer, Neurodegenerative Diseases, and Aging: Is VDAC1 a Common Target?
por: Shoshan-Barmatz, Varda, et al.
Publicado: (2021)

Probing key elements of teixobactin–lipid II interactions in membranes
por: Wen, Po-Chao, et al.
Publicado: (2018)

The Biogenesis Process of VDAC – From Early Cytosolic Events to Its Final Membrane Integration
por: Moitra, Anasuya, et al.
Publicado: (2021)

Redox-Sensitive VDAC: A Possible Function as an Environmental Stress Sensor Revealed by Bioinformatic Analysis
por: Karachitos, Andonis, et al.
Publicado: (2021)

Mitochondrial VDAC1: A Potential Therapeutic Target of Inflammation-Related Diseases and Clinical Opportunities
por: Hu, Hang, et al.
Publicado: (2022)

Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport
por: Kosyna, Friederike K., et al.
Publicado: (2018)

Differential effects of buffer pH on Ca(2+)-induced ROS emission with inhibited mitochondrial complexes I and III
por: Lindsay, Daniel P., et al.
Publicado: (2015)

Kras as a key oncogene and therapeutic target in pancreatic cancer
por: Collins, Meredith A., et al.
Publicado: (2014)

Controlling Parasympathetic Regulation of Heart Rate: A Gatekeeper Role for RGS Proteins in the Sinoatrial Node
por: Mighiu, Alexandra S., et al.
Publicado: (2012)

Noxa mitochondrial targeting domain induces necrosis via VDAC2 and mitochondrial catastrophe
por: Han, Ji-Hye, et al.
Publicado: (2019)

Ten Years of High Resolution Structural Research on the Voltage Dependent Anion Channel (VDAC)—Recent Developments and Future Directions
por: Zeth, Kornelius, et al.
Publicado: (2018)

Drosophila Porin/VDAC Affects Mitochondrial Morphology
por: Park, Jeehye, et al.
Publicado: (2010)

Computational Investigation of Cholesterol Binding Sites on Mitochondrial VDAC
por: Weiser, Brian P., et al.
Publicado: (2014)

The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation
por: Lauterwasser, Joachim, et al.
Publicado: (2016)

Ceramides bind VDAC2 to trigger mitochondrial apoptosis
por: Dadsena, Shashank, et al.
Publicado: (2019)

Cyclosporin A Increases Mitochondrial Buffering of Calcium: An Additional Mechanism in Delaying Mitochondrial Permeability Transition Pore Opening
por: Mishra, Jyotsna, et al.
Publicado: (2019)

Negative regulation of mitochondrial VDAC channels by C-Raf kinase
por: Le Mellay, Véronique, et al.
Publicado: (2002)

Aquaporin-7: A Dynamic Aquaglyceroporin With Greater Water and Glycerol Permeability Than Its Bacterial Homolog GlpF
por: Moss, Fraser J., et al.
Publicado: (2020)

Targeting Liver Cancer and Associated Pathologies in Mice with a Mitochondrial VDAC1-Based Peptide
por: Pittala, Srinivas, et al.
Publicado: (2018)

Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells
por: Heslop, Kareem A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_n940kh1dehiruipv34p5m4hc4j