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Chromosomal instability and lack of cyclin E regulation in hCdc4 mutant human breast cancer cells
INTRODUCTION: Cyclin E, a G(1 )cyclin essential for G(1)–S phase transition, is known to have a profound effect on tumorigenesis. Elevated levels of cyclin E have been associated with breast cancer, and chromosomal instability observed in breast cancer is suggested to be associated with constitutive...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549168/ https://www.ncbi.nlm.nih.gov/pubmed/15318934 http://dx.doi.org/10.1186/bcr900 |