PET Imaging of (18)F-FDG, (11)C-methionine, (11)C-flumazenil, and (11)C-4DST in Progressive Multifocal Leukoencephalopathy

The use of positron emission tomography (PET) imaging in progressive multifocal leukoencephalopathy (PML) has rarely been reported. We herein report a set of PET images in a 63-year-old patient with PML. In PML lesions, the uptake of (18)F-fluorodeoxyglucose, (11)C-methionine, (11)C-flumazenil, and...

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Autores principales: Ishibashi, Kenji, Miura, Yoshiharu, Matsumura, Ken, Kanemasa, Yusuke, Nakamichi, Kazuo, Saijo, Masayuki, Toyohara, Jun, Ishii, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491820/
https://www.ncbi.nlm.nih.gov/pubmed/28502940
http://dx.doi.org/10.2169/internalmedicine.56.8080
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author Ishibashi, Kenji
Miura, Yoshiharu
Matsumura, Ken
Kanemasa, Yusuke
Nakamichi, Kazuo
Saijo, Masayuki
Toyohara, Jun
Ishii, Kenji
author_facet Ishibashi, Kenji
Miura, Yoshiharu
Matsumura, Ken
Kanemasa, Yusuke
Nakamichi, Kazuo
Saijo, Masayuki
Toyohara, Jun
Ishii, Kenji
author_sort Ishibashi, Kenji
collection PubMed
description The use of positron emission tomography (PET) imaging in progressive multifocal leukoencephalopathy (PML) has rarely been reported. We herein report a set of PET images in a 63-year-old patient with PML. In PML lesions, the uptake of (18)F-fluorodeoxyglucose, (11)C-methionine, (11)C-flumazenil, and [methyl-(11)C]4′-thiothymidine was decreased, increased, decreased, and unchanged, respectively. These results suggest that glucose metabolism decreased, protein synthesis increased, neuronal integrity decreased, and the DNA synthesis and cellular proliferation of host cells were not activated in PML lesions. These results may reflect very little infiltration by inflammatory cells and active infection with JC virus in this case.
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spelling pubmed-54918202017-06-30 PET Imaging of (18)F-FDG, (11)C-methionine, (11)C-flumazenil, and (11)C-4DST in Progressive Multifocal Leukoencephalopathy Ishibashi, Kenji Miura, Yoshiharu Matsumura, Ken Kanemasa, Yusuke Nakamichi, Kazuo Saijo, Masayuki Toyohara, Jun Ishii, Kenji Intern Med Case Report The use of positron emission tomography (PET) imaging in progressive multifocal leukoencephalopathy (PML) has rarely been reported. We herein report a set of PET images in a 63-year-old patient with PML. In PML lesions, the uptake of (18)F-fluorodeoxyglucose, (11)C-methionine, (11)C-flumazenil, and [methyl-(11)C]4′-thiothymidine was decreased, increased, decreased, and unchanged, respectively. These results suggest that glucose metabolism decreased, protein synthesis increased, neuronal integrity decreased, and the DNA synthesis and cellular proliferation of host cells were not activated in PML lesions. These results may reflect very little infiltration by inflammatory cells and active infection with JC virus in this case. The Japanese Society of Internal Medicine 2017-05-15 /pmc/articles/PMC5491820/ /pubmed/28502940 http://dx.doi.org/10.2169/internalmedicine.56.8080 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ishibashi, Kenji
Miura, Yoshiharu
Matsumura, Ken
Kanemasa, Yusuke
Nakamichi, Kazuo
Saijo, Masayuki
Toyohara, Jun
Ishii, Kenji
PET Imaging of (18)F-FDG, (11)C-methionine, (11)C-flumazenil, and (11)C-4DST in Progressive Multifocal Leukoencephalopathy
title PET Imaging of (18)F-FDG, (11)C-methionine, (11)C-flumazenil, and (11)C-4DST in Progressive Multifocal Leukoencephalopathy
title_full PET Imaging of (18)F-FDG, (11)C-methionine, (11)C-flumazenil, and (11)C-4DST in Progressive Multifocal Leukoencephalopathy
title_fullStr PET Imaging of (18)F-FDG, (11)C-methionine, (11)C-flumazenil, and (11)C-4DST in Progressive Multifocal Leukoencephalopathy
title_full_unstemmed PET Imaging of (18)F-FDG, (11)C-methionine, (11)C-flumazenil, and (11)C-4DST in Progressive Multifocal Leukoencephalopathy
title_short PET Imaging of (18)F-FDG, (11)C-methionine, (11)C-flumazenil, and (11)C-4DST in Progressive Multifocal Leukoencephalopathy
title_sort pet imaging of (18)f-fdg, (11)c-methionine, (11)c-flumazenil, and (11)c-4dst in progressive multifocal leukoencephalopathy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491820/
https://www.ncbi.nlm.nih.gov/pubmed/28502940
http://dx.doi.org/10.2169/internalmedicine.56.8080
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