Brain Biopsy Is More Reliable than the DNA test for JC Virus in Cerebrospinal Fluid for the Diagnosis of Progressive Multifocal Leukoencephalopathy

The current standard diagnostic approach for progressive multifocal leukoencephalopathy (PML) is to perform a DNA test to identify the presence of the JC virus in cerebrospinal fluid (CSF). A 32-year-old woman with a 5-year history of systemic lupus erythematosus developed right hemiplegia and motor...

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Autores principales: Ikeda, Junji, Matsushima, Akira, Ishii, Wataru, Goto, Tetuya, Takahashi, Kenta, Nakamichi, Kazuo, Saijo, Masayuki, Sekijima, Yoshiki, Ikeda, Shu-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491822/
https://www.ncbi.nlm.nih.gov/pubmed/28502942
http://dx.doi.org/10.2169/internalmedicine.56.7689
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author Ikeda, Junji
Matsushima, Akira
Ishii, Wataru
Goto, Tetuya
Takahashi, Kenta
Nakamichi, Kazuo
Saijo, Masayuki
Sekijima, Yoshiki
Ikeda, Shu-ichi
author_facet Ikeda, Junji
Matsushima, Akira
Ishii, Wataru
Goto, Tetuya
Takahashi, Kenta
Nakamichi, Kazuo
Saijo, Masayuki
Sekijima, Yoshiki
Ikeda, Shu-ichi
author_sort Ikeda, Junji
collection PubMed
description The current standard diagnostic approach for progressive multifocal leukoencephalopathy (PML) is to perform a DNA test to identify the presence of the JC virus in cerebrospinal fluid (CSF). A 32-year-old woman with a 5-year history of systemic lupus erythematosus developed right hemiplegia and motor aphasia. MRI revealed a large white matter lesion in the left frontal lobe. JC virus DNA was undetectable in the CSF, but a brain biopsy showed typical histopathology and a high DNA load of the JC virus. The patient was treated with mefloquine and mirtazapine, and is currently alive at 24 months after onset. An early brain biopsy may therefore be important for making a timely diagnosis of PML.
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spelling pubmed-54918222017-06-30 Brain Biopsy Is More Reliable than the DNA test for JC Virus in Cerebrospinal Fluid for the Diagnosis of Progressive Multifocal Leukoencephalopathy Ikeda, Junji Matsushima, Akira Ishii, Wataru Goto, Tetuya Takahashi, Kenta Nakamichi, Kazuo Saijo, Masayuki Sekijima, Yoshiki Ikeda, Shu-ichi Intern Med Case Report The current standard diagnostic approach for progressive multifocal leukoencephalopathy (PML) is to perform a DNA test to identify the presence of the JC virus in cerebrospinal fluid (CSF). A 32-year-old woman with a 5-year history of systemic lupus erythematosus developed right hemiplegia and motor aphasia. MRI revealed a large white matter lesion in the left frontal lobe. JC virus DNA was undetectable in the CSF, but a brain biopsy showed typical histopathology and a high DNA load of the JC virus. The patient was treated with mefloquine and mirtazapine, and is currently alive at 24 months after onset. An early brain biopsy may therefore be important for making a timely diagnosis of PML. The Japanese Society of Internal Medicine 2017-05-15 /pmc/articles/PMC5491822/ /pubmed/28502942 http://dx.doi.org/10.2169/internalmedicine.56.7689 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ikeda, Junji
Matsushima, Akira
Ishii, Wataru
Goto, Tetuya
Takahashi, Kenta
Nakamichi, Kazuo
Saijo, Masayuki
Sekijima, Yoshiki
Ikeda, Shu-ichi
Brain Biopsy Is More Reliable than the DNA test for JC Virus in Cerebrospinal Fluid for the Diagnosis of Progressive Multifocal Leukoencephalopathy
title Brain Biopsy Is More Reliable than the DNA test for JC Virus in Cerebrospinal Fluid for the Diagnosis of Progressive Multifocal Leukoencephalopathy
title_full Brain Biopsy Is More Reliable than the DNA test for JC Virus in Cerebrospinal Fluid for the Diagnosis of Progressive Multifocal Leukoencephalopathy
title_fullStr Brain Biopsy Is More Reliable than the DNA test for JC Virus in Cerebrospinal Fluid for the Diagnosis of Progressive Multifocal Leukoencephalopathy
title_full_unstemmed Brain Biopsy Is More Reliable than the DNA test for JC Virus in Cerebrospinal Fluid for the Diagnosis of Progressive Multifocal Leukoencephalopathy
title_short Brain Biopsy Is More Reliable than the DNA test for JC Virus in Cerebrospinal Fluid for the Diagnosis of Progressive Multifocal Leukoencephalopathy
title_sort brain biopsy is more reliable than the dna test for jc virus in cerebrospinal fluid for the diagnosis of progressive multifocal leukoencephalopathy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491822/
https://www.ncbi.nlm.nih.gov/pubmed/28502942
http://dx.doi.org/10.2169/internalmedicine.56.7689
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