Cargando…
The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome
We report a case of cerebral venous thrombosis related to the ingestion of tadalafil. A 45-year-old man presented with posterior headache and was diagnosed with tension headache. Five days later, he was transported to our hospital via ambulance due to a tonic-clonic seizure. Head MRI showed cerebral...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491823/ https://www.ncbi.nlm.nih.gov/pubmed/28502943 http://dx.doi.org/10.2169/internalmedicine.56.7864 |
_version_ | 1783247203596238848 |
---|---|
author | Numata, Kenji Shimoda, Kouhei Shibata, Yasushi Shioya, Ayako Tokuda, Yasuharu |
author_facet | Numata, Kenji Shimoda, Kouhei Shibata, Yasushi Shioya, Ayako Tokuda, Yasuharu |
author_sort | Numata, Kenji |
collection | PubMed |
description | We report a case of cerebral venous thrombosis related to the ingestion of tadalafil. A 45-year-old man presented with posterior headache and was diagnosed with tension headache. Five days later, he was transported to our hospital via ambulance due to a tonic-clonic seizure. Head MRI showed cerebral venous thrombosis (CVT). He confessed to having recently taken a large doses of tadalafil. His anti-cardiolipin antibody and anti-caldiolipin-β2-glycoprotein-I complex antibody levels were elevated. Our case suggests the possibility that tadalafil is related to both cardiovascular complications and CVT in patients with hypercoagulability. Patients with conditions associated with hypercoagulability, including antiphospholipid syndrome may be better advised to avoid the use of tadalafil. |
format | Online Article Text |
id | pubmed-5491823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-54918232017-06-30 The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome Numata, Kenji Shimoda, Kouhei Shibata, Yasushi Shioya, Ayako Tokuda, Yasuharu Intern Med Case Report We report a case of cerebral venous thrombosis related to the ingestion of tadalafil. A 45-year-old man presented with posterior headache and was diagnosed with tension headache. Five days later, he was transported to our hospital via ambulance due to a tonic-clonic seizure. Head MRI showed cerebral venous thrombosis (CVT). He confessed to having recently taken a large doses of tadalafil. His anti-cardiolipin antibody and anti-caldiolipin-β2-glycoprotein-I complex antibody levels were elevated. Our case suggests the possibility that tadalafil is related to both cardiovascular complications and CVT in patients with hypercoagulability. Patients with conditions associated with hypercoagulability, including antiphospholipid syndrome may be better advised to avoid the use of tadalafil. The Japanese Society of Internal Medicine 2017-05-15 /pmc/articles/PMC5491823/ /pubmed/28502943 http://dx.doi.org/10.2169/internalmedicine.56.7864 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Numata, Kenji Shimoda, Kouhei Shibata, Yasushi Shioya, Ayako Tokuda, Yasuharu The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome |
title | The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome |
title_full | The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome |
title_fullStr | The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome |
title_full_unstemmed | The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome |
title_short | The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome |
title_sort | development of cerebral venous thrombosis after tadalafil ingestion in a patient with antiphospholipid syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491823/ https://www.ncbi.nlm.nih.gov/pubmed/28502943 http://dx.doi.org/10.2169/internalmedicine.56.7864 |
work_keys_str_mv | AT numatakenji thedevelopmentofcerebralvenousthrombosisaftertadalafilingestioninapatientwithantiphospholipidsyndrome AT shimodakouhei thedevelopmentofcerebralvenousthrombosisaftertadalafilingestioninapatientwithantiphospholipidsyndrome AT shibatayasushi thedevelopmentofcerebralvenousthrombosisaftertadalafilingestioninapatientwithantiphospholipidsyndrome AT shioyaayako thedevelopmentofcerebralvenousthrombosisaftertadalafilingestioninapatientwithantiphospholipidsyndrome AT tokudayasuharu thedevelopmentofcerebralvenousthrombosisaftertadalafilingestioninapatientwithantiphospholipidsyndrome AT numatakenji developmentofcerebralvenousthrombosisaftertadalafilingestioninapatientwithantiphospholipidsyndrome AT shimodakouhei developmentofcerebralvenousthrombosisaftertadalafilingestioninapatientwithantiphospholipidsyndrome AT shibatayasushi developmentofcerebralvenousthrombosisaftertadalafilingestioninapatientwithantiphospholipidsyndrome AT shioyaayako developmentofcerebralvenousthrombosisaftertadalafilingestioninapatientwithantiphospholipidsyndrome AT tokudayasuharu developmentofcerebralvenousthrombosisaftertadalafilingestioninapatientwithantiphospholipidsyndrome |