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The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome

We report a case of cerebral venous thrombosis related to the ingestion of tadalafil. A 45-year-old man presented with posterior headache and was diagnosed with tension headache. Five days later, he was transported to our hospital via ambulance due to a tonic-clonic seizure. Head MRI showed cerebral...

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Autores principales: Numata, Kenji, Shimoda, Kouhei, Shibata, Yasushi, Shioya, Ayako, Tokuda, Yasuharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491823/
https://www.ncbi.nlm.nih.gov/pubmed/28502943
http://dx.doi.org/10.2169/internalmedicine.56.7864
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author Numata, Kenji
Shimoda, Kouhei
Shibata, Yasushi
Shioya, Ayako
Tokuda, Yasuharu
author_facet Numata, Kenji
Shimoda, Kouhei
Shibata, Yasushi
Shioya, Ayako
Tokuda, Yasuharu
author_sort Numata, Kenji
collection PubMed
description We report a case of cerebral venous thrombosis related to the ingestion of tadalafil. A 45-year-old man presented with posterior headache and was diagnosed with tension headache. Five days later, he was transported to our hospital via ambulance due to a tonic-clonic seizure. Head MRI showed cerebral venous thrombosis (CVT). He confessed to having recently taken a large doses of tadalafil. His anti-cardiolipin antibody and anti-caldiolipin-β2-glycoprotein-I complex antibody levels were elevated. Our case suggests the possibility that tadalafil is related to both cardiovascular complications and CVT in patients with hypercoagulability. Patients with conditions associated with hypercoagulability, including antiphospholipid syndrome may be better advised to avoid the use of tadalafil.
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spelling pubmed-54918232017-06-30 The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome Numata, Kenji Shimoda, Kouhei Shibata, Yasushi Shioya, Ayako Tokuda, Yasuharu Intern Med Case Report We report a case of cerebral venous thrombosis related to the ingestion of tadalafil. A 45-year-old man presented with posterior headache and was diagnosed with tension headache. Five days later, he was transported to our hospital via ambulance due to a tonic-clonic seizure. Head MRI showed cerebral venous thrombosis (CVT). He confessed to having recently taken a large doses of tadalafil. His anti-cardiolipin antibody and anti-caldiolipin-β2-glycoprotein-I complex antibody levels were elevated. Our case suggests the possibility that tadalafil is related to both cardiovascular complications and CVT in patients with hypercoagulability. Patients with conditions associated with hypercoagulability, including antiphospholipid syndrome may be better advised to avoid the use of tadalafil. The Japanese Society of Internal Medicine 2017-05-15 /pmc/articles/PMC5491823/ /pubmed/28502943 http://dx.doi.org/10.2169/internalmedicine.56.7864 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Numata, Kenji
Shimoda, Kouhei
Shibata, Yasushi
Shioya, Ayako
Tokuda, Yasuharu
The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome
title The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome
title_full The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome
title_fullStr The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome
title_full_unstemmed The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome
title_short The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome
title_sort development of cerebral venous thrombosis after tadalafil ingestion in a patient with antiphospholipid syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491823/
https://www.ncbi.nlm.nih.gov/pubmed/28502943
http://dx.doi.org/10.2169/internalmedicine.56.7864
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