In vitro and in vivo anticancer studies of 2'-hydroxy chalcone derivatives exhibit apoptosis in colon cancer cells by HDAC inhibition and cell cycle arrest

Considering the therapeutic values of bioflavonoids in colon cancer treatment, six 2ʹ-hydroxy chalcones (C1-C6) were synthesized, characterized and screened for in vitro cytotoxicity on human colon carcinoma (HCT116) and African green monkey kidney epithelial cells (Vero). Only C5 showed selective c...

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Detalles Bibliográficos
Autores principales: Pande, Aditya Narayan, Biswas, Subhankar, Reddy, Neetinkumar D., Jayashree, B.S., Kumar, Nitesh, Rao, C. Mallikarjuna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491917/
https://www.ncbi.nlm.nih.gov/pubmed/28694750
http://dx.doi.org/10.17179/excli2016-643

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