Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications

The unique features of gamma-delta (γδ) T cells, related to their antigen recognition capacity, their tissue tropism, and their cytotoxic function, make these cells ideal candidates that could be targeted to induce durable immunity in the context of different pathologies. In this review, we focus on...

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Autores principales: Lawand, Myriam, Déchanet-Merville, Julie, Dieu-Nosjean, Marie-Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491929/
https://www.ncbi.nlm.nih.gov/pubmed/28713381
http://dx.doi.org/10.3389/fimmu.2017.00761
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author Lawand, Myriam
Déchanet-Merville, Julie
Dieu-Nosjean, Marie-Caroline
author_facet Lawand, Myriam
Déchanet-Merville, Julie
Dieu-Nosjean, Marie-Caroline
author_sort Lawand, Myriam
collection PubMed
description The unique features of gamma-delta (γδ) T cells, related to their antigen recognition capacity, their tissue tropism, and their cytotoxic function, make these cells ideal candidates that could be targeted to induce durable immunity in the context of different pathologies. In this review, we focus on the main characteristics of human γδ T-cell subsets in diseases and the key mechanisms that could be explored to target these cells.
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spelling pubmed-54919292017-07-14 Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications Lawand, Myriam Déchanet-Merville, Julie Dieu-Nosjean, Marie-Caroline Front Immunol Immunology The unique features of gamma-delta (γδ) T cells, related to their antigen recognition capacity, their tissue tropism, and their cytotoxic function, make these cells ideal candidates that could be targeted to induce durable immunity in the context of different pathologies. In this review, we focus on the main characteristics of human γδ T-cell subsets in diseases and the key mechanisms that could be explored to target these cells. Frontiers Media S.A. 2017-06-30 /pmc/articles/PMC5491929/ /pubmed/28713381 http://dx.doi.org/10.3389/fimmu.2017.00761 Text en Copyright © 2017 Lawand, Déchanet-Merville and Dieu-Nosjean. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Lawand, Myriam
Déchanet-Merville, Julie
Dieu-Nosjean, Marie-Caroline
Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications
title Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications
title_full Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications
title_fullStr Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications
title_full_unstemmed Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications
title_short Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications
title_sort key features of gamma-delta t-cell subsets in human diseases and their immunotherapeutic implications
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491929/
https://www.ncbi.nlm.nih.gov/pubmed/28713381
http://dx.doi.org/10.3389/fimmu.2017.00761
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