Microinjection of Antibodies Targeting the Lamin A/C Histone-Binding Site Blocks Mitotic Entry and Reveals Separate Chromatin Interactions with HP1, CenpB and PML

Lamins form a scaffold lining the nucleus that binds chromatin and contributes to spatial genome organization; however, due to the many other functions of lamins, studies knocking out or altering the lamin polymer cannot clearly distinguish between direct and indirect effects. To overcome this obsta...

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Detalles Bibliográficos
Autores principales: Dixon, Charles R., Platani, Melpomeni, Makarov, Alexandr A., Schirmer, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492013/
https://www.ncbi.nlm.nih.gov/pubmed/28346356
http://dx.doi.org/10.3390/cells6020009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492013/
https://www.ncbi.nlm.nih.gov/pubmed/28346356
http://dx.doi.org/10.3390/cells6020009

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