Peptidyl Transferase Center and the Emergence of the Translation System

In this work, the three-dimensional (3D) structure of the ancestral Peptidyl Transferase Center (PTC) built by concatamers of ancestral sequences of tRNAs was reconstructed, and its possible interactions with tRNAs molecules were analyzed. The 3D structure of the ancestral PTC was also compared with...

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Autores principales: Torres de Farias, Savio, Gaudêncio Rêgo, Thais, José, Marco V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492143/
https://www.ncbi.nlm.nih.gov/pubmed/28441334
http://dx.doi.org/10.3390/life7020021
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author Torres de Farias, Savio
Gaudêncio Rêgo, Thais
José, Marco V.
author_facet Torres de Farias, Savio
Gaudêncio Rêgo, Thais
José, Marco V.
author_sort Torres de Farias, Savio
collection PubMed
description In this work, the three-dimensional (3D) structure of the ancestral Peptidyl Transferase Center (PTC) built by concatamers of ancestral sequences of tRNAs was reconstructed, and its possible interactions with tRNAs molecules were analyzed. The 3D structure of the ancestral PTC was also compared with the current PTC of T. thermophilus. Docking experiments between the ancestral PTC and tRNAs suggest that in the origin of the translation system, the PTC functioned as an adhesion center for tRNA molecules. The approximation of tRNAs charged with amino acids to the PTC permitted peptide synthesis without the need of a genetic code.
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spelling pubmed-54921432017-07-03 Peptidyl Transferase Center and the Emergence of the Translation System Torres de Farias, Savio Gaudêncio Rêgo, Thais José, Marco V. Life (Basel) Article In this work, the three-dimensional (3D) structure of the ancestral Peptidyl Transferase Center (PTC) built by concatamers of ancestral sequences of tRNAs was reconstructed, and its possible interactions with tRNAs molecules were analyzed. The 3D structure of the ancestral PTC was also compared with the current PTC of T. thermophilus. Docking experiments between the ancestral PTC and tRNAs suggest that in the origin of the translation system, the PTC functioned as an adhesion center for tRNA molecules. The approximation of tRNAs charged with amino acids to the PTC permitted peptide synthesis without the need of a genetic code. MDPI 2017-04-25 /pmc/articles/PMC5492143/ /pubmed/28441334 http://dx.doi.org/10.3390/life7020021 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Torres de Farias, Savio
Gaudêncio Rêgo, Thais
José, Marco V.
Peptidyl Transferase Center and the Emergence of the Translation System
title Peptidyl Transferase Center and the Emergence of the Translation System
title_full Peptidyl Transferase Center and the Emergence of the Translation System
title_fullStr Peptidyl Transferase Center and the Emergence of the Translation System
title_full_unstemmed Peptidyl Transferase Center and the Emergence of the Translation System
title_short Peptidyl Transferase Center and the Emergence of the Translation System
title_sort peptidyl transferase center and the emergence of the translation system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492143/
https://www.ncbi.nlm.nih.gov/pubmed/28441334
http://dx.doi.org/10.3390/life7020021
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AT gaudencioregothais peptidyltransferasecenterandtheemergenceofthetranslationsystem
AT josemarcov peptidyltransferasecenterandtheemergenceofthetranslationsystem

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