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Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: A contemporary review of experimental studies
OBJECTIVES: Distraction osteogenesis (DO) mobilises bone regenerative potential and avoids the complications of other treatments such as bone graft. The major disadvantage of DO is the length of time required for bone consolidation. Mesenchymal stem cells (MSCs) have been used to promote bone format...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492338/ https://www.ncbi.nlm.nih.gov/pubmed/28634158 http://dx.doi.org/10.1302/2046-3758.66.BJR-2017-0023 |
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author | Yang, Y. Lin, S. Wang, B. Gu, W. Li, G. |
author_facet | Yang, Y. Lin, S. Wang, B. Gu, W. Li, G. |
author_sort | Yang, Y. |
collection | PubMed |
description | OBJECTIVES: Distraction osteogenesis (DO) mobilises bone regenerative potential and avoids the complications of other treatments such as bone graft. The major disadvantage of DO is the length of time required for bone consolidation. Mesenchymal stem cells (MSCs) have been used to promote bone formation with some good results. METHODS: We hereby review the published literature on the use of MSCs in promoting bone consolidation during DO. RESULTS: Studies differed in animal type (mice, rabbit, dog, sheep), bone type (femur, tibia, skull), DO protocols and cell transplantation methods. CONCLUSION: The majority of studies reported that the transplantation of MSCs enhanced bone consolidation or formation in DO. Many questions relating to animal model, DO protocol and cell transplantation regime remain to be further investigated. Clinical trials are needed to test and confirm these findings from animal studies. Cite this article: Y. Yang, S. Lin, B. Wang, W. Gu, G. Li. Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: A contemporary review of experimental studies. Bone Joint Res 2017;6:385–390. DOI: 10.1302/2046-3758.66.BJR-2017-0023. |
format | Online Article Text |
id | pubmed-5492338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
record_format | MEDLINE/PubMed |
spelling | pubmed-54923382017-07-10 Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: A contemporary review of experimental studies Yang, Y. Lin, S. Wang, B. Gu, W. Li, G. Bone Joint Res Research OBJECTIVES: Distraction osteogenesis (DO) mobilises bone regenerative potential and avoids the complications of other treatments such as bone graft. The major disadvantage of DO is the length of time required for bone consolidation. Mesenchymal stem cells (MSCs) have been used to promote bone formation with some good results. METHODS: We hereby review the published literature on the use of MSCs in promoting bone consolidation during DO. RESULTS: Studies differed in animal type (mice, rabbit, dog, sheep), bone type (femur, tibia, skull), DO protocols and cell transplantation methods. CONCLUSION: The majority of studies reported that the transplantation of MSCs enhanced bone consolidation or formation in DO. Many questions relating to animal model, DO protocol and cell transplantation regime remain to be further investigated. Clinical trials are needed to test and confirm these findings from animal studies. Cite this article: Y. Yang, S. Lin, B. Wang, W. Gu, G. Li. Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: A contemporary review of experimental studies. Bone Joint Res 2017;6:385–390. DOI: 10.1302/2046-3758.66.BJR-2017-0023. 2017-06-30 /pmc/articles/PMC5492338/ /pubmed/28634158 http://dx.doi.org/10.1302/2046-3758.66.BJR-2017-0023 Text en © 2017 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attributions licence (CC-BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, but not for commercial gain, provided the original author and source are credited. |
spellingShingle | Research Yang, Y. Lin, S. Wang, B. Gu, W. Li, G. Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: A contemporary review of experimental studies |
title | Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: A contemporary review of experimental studies |
title_full | Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: A contemporary review of experimental studies |
title_fullStr | Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: A contemporary review of experimental studies |
title_full_unstemmed | Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: A contemporary review of experimental studies |
title_short | Stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: A contemporary review of experimental studies |
title_sort | stem cell therapy for enhancement of bone consolidation in distraction osteogenesis: a contemporary review of experimental studies |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492338/ https://www.ncbi.nlm.nih.gov/pubmed/28634158 http://dx.doi.org/10.1302/2046-3758.66.BJR-2017-0023 |
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