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In vivo and clinical application of strontium-enriched biomaterials for bone regeneration: A systematic review

OBJECTIVES: This systematic review aimed to assess the in vivo and clinical effect of strontium (Sr)-enriched biomaterials in bone formation and/or remodelling. METHODS: A systematic search was performed in Pubmed, followed by a two-step selection process. We included in vivo original studies on Sr-...

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Autores principales: Neves, N., Linhares, D., Costa, G., Ribeiro, C. C., Barbosa, M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492369/
https://www.ncbi.nlm.nih.gov/pubmed/28600382
http://dx.doi.org/10.1302/2046-3758.66.BJR-2016-0311.R1
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author Neves, N.
Linhares, D.
Costa, G.
Ribeiro, C. C.
Barbosa, M. A.
author_facet Neves, N.
Linhares, D.
Costa, G.
Ribeiro, C. C.
Barbosa, M. A.
author_sort Neves, N.
collection PubMed
description OBJECTIVES: This systematic review aimed to assess the in vivo and clinical effect of strontium (Sr)-enriched biomaterials in bone formation and/or remodelling. METHODS: A systematic search was performed in Pubmed, followed by a two-step selection process. We included in vivo original studies on Sr-containing biomaterials used for bone support or regeneration, comparing at least two groups that only differ in Sr addition in the experimental group. RESULTS: A total of 572 references were retrieved and 27 were included. Animal models were used in 26 articles, and one article described a human study. Osteoporotic models were included in 11 papers. All articles showed similar or increased effect of Sr in bone formation and/or regeneration, in both healthy and osteoporotic models. No study found a decreased effect. Adverse effects were assessed in 17 articles, 13 on local and four on systemic adverse effects. From these, only one reported a systemic impact from Sr addition. Data on gene and/or protein expression were available from seven studies. CONCLUSIONS: This review showed the safety and effectiveness of Sr-enriched biomaterials for stimulating bone formation and remodelling in animal models. The effect seems to increase over time and is impacted by the concentration used. However, included studies present a wide range of study methods. Future work should focus on consistent models and guidelines when developing a future clinical application of this element. Cite this article: N. Neves, D. Linhares, G. Costa, C. C. Ribeiro, M. A. Barbosa. In vivo and clinical application of strontium-enriched biomaterials for bone regeneration: A systematic review. Bone Joint Res 2017;6:366–375. DOI: 10.1302/2046-3758.66.BJR-2016-0311.R1.
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spelling pubmed-54923692017-07-10 In vivo and clinical application of strontium-enriched biomaterials for bone regeneration: A systematic review Neves, N. Linhares, D. Costa, G. Ribeiro, C. C. Barbosa, M. A. Bone Joint Res Research OBJECTIVES: This systematic review aimed to assess the in vivo and clinical effect of strontium (Sr)-enriched biomaterials in bone formation and/or remodelling. METHODS: A systematic search was performed in Pubmed, followed by a two-step selection process. We included in vivo original studies on Sr-containing biomaterials used for bone support or regeneration, comparing at least two groups that only differ in Sr addition in the experimental group. RESULTS: A total of 572 references were retrieved and 27 were included. Animal models were used in 26 articles, and one article described a human study. Osteoporotic models were included in 11 papers. All articles showed similar or increased effect of Sr in bone formation and/or regeneration, in both healthy and osteoporotic models. No study found a decreased effect. Adverse effects were assessed in 17 articles, 13 on local and four on systemic adverse effects. From these, only one reported a systemic impact from Sr addition. Data on gene and/or protein expression were available from seven studies. CONCLUSIONS: This review showed the safety and effectiveness of Sr-enriched biomaterials for stimulating bone formation and remodelling in animal models. The effect seems to increase over time and is impacted by the concentration used. However, included studies present a wide range of study methods. Future work should focus on consistent models and guidelines when developing a future clinical application of this element. Cite this article: N. Neves, D. Linhares, G. Costa, C. C. Ribeiro, M. A. Barbosa. In vivo and clinical application of strontium-enriched biomaterials for bone regeneration: A systematic review. Bone Joint Res 2017;6:366–375. DOI: 10.1302/2046-3758.66.BJR-2016-0311.R1. 2017-06-30 /pmc/articles/PMC5492369/ /pubmed/28600382 http://dx.doi.org/10.1302/2046-3758.66.BJR-2016-0311.R1 Text en © 2017 Neves et al. This is an open-access article distributed under the terms of the Creative Commons Attributions licence (CC-BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, but not for commercial gain, provided the original author and source are credited.
spellingShingle Research
Neves, N.
Linhares, D.
Costa, G.
Ribeiro, C. C.
Barbosa, M. A.
In vivo and clinical application of strontium-enriched biomaterials for bone regeneration: A systematic review
title In vivo and clinical application of strontium-enriched biomaterials for bone regeneration: A systematic review
title_full In vivo and clinical application of strontium-enriched biomaterials for bone regeneration: A systematic review
title_fullStr In vivo and clinical application of strontium-enriched biomaterials for bone regeneration: A systematic review
title_full_unstemmed In vivo and clinical application of strontium-enriched biomaterials for bone regeneration: A systematic review
title_short In vivo and clinical application of strontium-enriched biomaterials for bone regeneration: A systematic review
title_sort in vivo and clinical application of strontium-enriched biomaterials for bone regeneration: a systematic review
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492369/
https://www.ncbi.nlm.nih.gov/pubmed/28600382
http://dx.doi.org/10.1302/2046-3758.66.BJR-2016-0311.R1
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