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Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs

The imbalance between limited organ supply and huge potential need has hindered the development of organ-graft techniques. In this paper a low-cost hypothermic machine perfusion (HMP) device is designed and implemented to maintain suitable preservation surroundings and extend the survival life of is...

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Detalles Bibliográficos
Autores principales: Shen, Fei, Yan, Ruqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492428/
https://www.ncbi.nlm.nih.gov/pubmed/28587173
http://dx.doi.org/10.3390/s17061256
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author Shen, Fei
Yan, Ruqiang
author_facet Shen, Fei
Yan, Ruqiang
author_sort Shen, Fei
collection PubMed
description The imbalance between limited organ supply and huge potential need has hindered the development of organ-graft techniques. In this paper a low-cost hypothermic machine perfusion (HMP) device is designed and implemented to maintain suitable preservation surroundings and extend the survival life of isolated organs. Four necessary elements (the machine perfusion, the physiological parameter monitoring, the thermostatic control and the oxygenation apparatus) involved in this HMP device are introduced. Especially during the thermostatic control process, a modified Bayes estimation, which introduces the concept of improvement factor, is realized to recognize and reduce the possible measurement errors resulting from sensor faults and noise interference. Also, a fuzzy-PID controller contributes to improve the accuracy and reduces the computational load using the DSP. Our experiments indicate that the reliability of the instrument meets the design requirements, thus being appealing for potential clinical preservation applications.
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spelling pubmed-54924282017-07-03 Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs Shen, Fei Yan, Ruqiang Sensors (Basel) Article The imbalance between limited organ supply and huge potential need has hindered the development of organ-graft techniques. In this paper a low-cost hypothermic machine perfusion (HMP) device is designed and implemented to maintain suitable preservation surroundings and extend the survival life of isolated organs. Four necessary elements (the machine perfusion, the physiological parameter monitoring, the thermostatic control and the oxygenation apparatus) involved in this HMP device are introduced. Especially during the thermostatic control process, a modified Bayes estimation, which introduces the concept of improvement factor, is realized to recognize and reduce the possible measurement errors resulting from sensor faults and noise interference. Also, a fuzzy-PID controller contributes to improve the accuracy and reduces the computational load using the DSP. Our experiments indicate that the reliability of the instrument meets the design requirements, thus being appealing for potential clinical preservation applications. MDPI 2017-06-01 /pmc/articles/PMC5492428/ /pubmed/28587173 http://dx.doi.org/10.3390/s17061256 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shen, Fei
Yan, Ruqiang
Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs
title Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs
title_full Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs
title_fullStr Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs
title_full_unstemmed Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs
title_short Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs
title_sort design and implementation of a hypothermic machine perfusion device for clinical preservation of isolated organs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492428/
https://www.ncbi.nlm.nih.gov/pubmed/28587173
http://dx.doi.org/10.3390/s17061256
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