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Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs
The imbalance between limited organ supply and huge potential need has hindered the development of organ-graft techniques. In this paper a low-cost hypothermic machine perfusion (HMP) device is designed and implemented to maintain suitable preservation surroundings and extend the survival life of is...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492428/ https://www.ncbi.nlm.nih.gov/pubmed/28587173 http://dx.doi.org/10.3390/s17061256 |
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author | Shen, Fei Yan, Ruqiang |
author_facet | Shen, Fei Yan, Ruqiang |
author_sort | Shen, Fei |
collection | PubMed |
description | The imbalance between limited organ supply and huge potential need has hindered the development of organ-graft techniques. In this paper a low-cost hypothermic machine perfusion (HMP) device is designed and implemented to maintain suitable preservation surroundings and extend the survival life of isolated organs. Four necessary elements (the machine perfusion, the physiological parameter monitoring, the thermostatic control and the oxygenation apparatus) involved in this HMP device are introduced. Especially during the thermostatic control process, a modified Bayes estimation, which introduces the concept of improvement factor, is realized to recognize and reduce the possible measurement errors resulting from sensor faults and noise interference. Also, a fuzzy-PID controller contributes to improve the accuracy and reduces the computational load using the DSP. Our experiments indicate that the reliability of the instrument meets the design requirements, thus being appealing for potential clinical preservation applications. |
format | Online Article Text |
id | pubmed-5492428 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54924282017-07-03 Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs Shen, Fei Yan, Ruqiang Sensors (Basel) Article The imbalance between limited organ supply and huge potential need has hindered the development of organ-graft techniques. In this paper a low-cost hypothermic machine perfusion (HMP) device is designed and implemented to maintain suitable preservation surroundings and extend the survival life of isolated organs. Four necessary elements (the machine perfusion, the physiological parameter monitoring, the thermostatic control and the oxygenation apparatus) involved in this HMP device are introduced. Especially during the thermostatic control process, a modified Bayes estimation, which introduces the concept of improvement factor, is realized to recognize and reduce the possible measurement errors resulting from sensor faults and noise interference. Also, a fuzzy-PID controller contributes to improve the accuracy and reduces the computational load using the DSP. Our experiments indicate that the reliability of the instrument meets the design requirements, thus being appealing for potential clinical preservation applications. MDPI 2017-06-01 /pmc/articles/PMC5492428/ /pubmed/28587173 http://dx.doi.org/10.3390/s17061256 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shen, Fei Yan, Ruqiang Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs |
title | Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs |
title_full | Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs |
title_fullStr | Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs |
title_full_unstemmed | Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs |
title_short | Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs |
title_sort | design and implementation of a hypothermic machine perfusion device for clinical preservation of isolated organs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492428/ https://www.ncbi.nlm.nih.gov/pubmed/28587173 http://dx.doi.org/10.3390/s17061256 |
work_keys_str_mv | AT shenfei designandimplementationofahypothermicmachineperfusiondeviceforclinicalpreservationofisolatedorgans AT yanruqiang designandimplementationofahypothermicmachineperfusiondeviceforclinicalpreservationofisolatedorgans |