Cargando…

Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support

Plasmonic nanostructures are widely used for various sensing applications by monitoring changes in refractive index through optical spectroscopy or as substrates for surface enhanced Raman spectroscopy. However, in most practical situations conventional surface plasmon resonance is preferred for bio...

Descripción completa

Detalles Bibliográficos
Autores principales: Malekian, Bita, Xiong, Kunli, Emilsson, Gustav, Andersson, Jenny, Fager, Cecilia, Olsson, Eva, Larsson-Langhammer, Elin M., Dahlin, Andreas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492491/
https://www.ncbi.nlm.nih.gov/pubmed/28632153
http://dx.doi.org/10.3390/s17061444
_version_ 1783247342565064704
author Malekian, Bita
Xiong, Kunli
Emilsson, Gustav
Andersson, Jenny
Fager, Cecilia
Olsson, Eva
Larsson-Langhammer, Elin M.
Dahlin, Andreas B.
author_facet Malekian, Bita
Xiong, Kunli
Emilsson, Gustav
Andersson, Jenny
Fager, Cecilia
Olsson, Eva
Larsson-Langhammer, Elin M.
Dahlin, Andreas B.
author_sort Malekian, Bita
collection PubMed
description Plasmonic nanostructures are widely used for various sensing applications by monitoring changes in refractive index through optical spectroscopy or as substrates for surface enhanced Raman spectroscopy. However, in most practical situations conventional surface plasmon resonance is preferred for biomolecular interaction analysis because of its high resolution in surface coverage and the simple single-material planar interface. Still, plasmonic nanostructures may find unique sensing applications, for instance when the nanoscale geometry itself is of interest. This calls for new methods to prepare nanoscale particles and cavities with controllable dimensions and curvature. In this work, we present two types of plasmonic nanopores where the solid support underneath a nanohole array has been etched, thereby creating cavities denoted as ‘nanowells’ or ‘nanocaves’ depending on the degree of anisotropy (dry or wet etch). The refractometric sensitivity is shown to be enhanced upon removing the solid support because of an increased probing volume and a shift of the asymmetric plasmonic field towards the liquid side of the finite gold film. Furthermore, the structures exhibit different spectral changes upon binding inside the cavities compared to the gold surface, which means that the structures can be used for location-specific detection. Other sensing applications are also suggested.
format Online
Article
Text
id pubmed-5492491
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-54924912017-07-03 Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support Malekian, Bita Xiong, Kunli Emilsson, Gustav Andersson, Jenny Fager, Cecilia Olsson, Eva Larsson-Langhammer, Elin M. Dahlin, Andreas B. Sensors (Basel) Article Plasmonic nanostructures are widely used for various sensing applications by monitoring changes in refractive index through optical spectroscopy or as substrates for surface enhanced Raman spectroscopy. However, in most practical situations conventional surface plasmon resonance is preferred for biomolecular interaction analysis because of its high resolution in surface coverage and the simple single-material planar interface. Still, plasmonic nanostructures may find unique sensing applications, for instance when the nanoscale geometry itself is of interest. This calls for new methods to prepare nanoscale particles and cavities with controllable dimensions and curvature. In this work, we present two types of plasmonic nanopores where the solid support underneath a nanohole array has been etched, thereby creating cavities denoted as ‘nanowells’ or ‘nanocaves’ depending on the degree of anisotropy (dry or wet etch). The refractometric sensitivity is shown to be enhanced upon removing the solid support because of an increased probing volume and a shift of the asymmetric plasmonic field towards the liquid side of the finite gold film. Furthermore, the structures exhibit different spectral changes upon binding inside the cavities compared to the gold surface, which means that the structures can be used for location-specific detection. Other sensing applications are also suggested. MDPI 2017-06-20 /pmc/articles/PMC5492491/ /pubmed/28632153 http://dx.doi.org/10.3390/s17061444 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Malekian, Bita
Xiong, Kunli
Emilsson, Gustav
Andersson, Jenny
Fager, Cecilia
Olsson, Eva
Larsson-Langhammer, Elin M.
Dahlin, Andreas B.
Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support
title Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support
title_full Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support
title_fullStr Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support
title_full_unstemmed Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support
title_short Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support
title_sort fabrication and characterization of plasmonic nanopores with cavities in the solid support
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492491/
https://www.ncbi.nlm.nih.gov/pubmed/28632153
http://dx.doi.org/10.3390/s17061444
work_keys_str_mv AT malekianbita fabricationandcharacterizationofplasmonicnanoporeswithcavitiesinthesolidsupport
AT xiongkunli fabricationandcharacterizationofplasmonicnanoporeswithcavitiesinthesolidsupport
AT emilssongustav fabricationandcharacterizationofplasmonicnanoporeswithcavitiesinthesolidsupport
AT anderssonjenny fabricationandcharacterizationofplasmonicnanoporeswithcavitiesinthesolidsupport
AT fagercecilia fabricationandcharacterizationofplasmonicnanoporeswithcavitiesinthesolidsupport
AT olssoneva fabricationandcharacterizationofplasmonicnanoporeswithcavitiesinthesolidsupport
AT larssonlanghammerelinm fabricationandcharacterizationofplasmonicnanoporeswithcavitiesinthesolidsupport
AT dahlinandreasb fabricationandcharacterizationofplasmonicnanoporeswithcavitiesinthesolidsupport