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Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support
Plasmonic nanostructures are widely used for various sensing applications by monitoring changes in refractive index through optical spectroscopy or as substrates for surface enhanced Raman spectroscopy. However, in most practical situations conventional surface plasmon resonance is preferred for bio...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492491/ https://www.ncbi.nlm.nih.gov/pubmed/28632153 http://dx.doi.org/10.3390/s17061444 |
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author | Malekian, Bita Xiong, Kunli Emilsson, Gustav Andersson, Jenny Fager, Cecilia Olsson, Eva Larsson-Langhammer, Elin M. Dahlin, Andreas B. |
author_facet | Malekian, Bita Xiong, Kunli Emilsson, Gustav Andersson, Jenny Fager, Cecilia Olsson, Eva Larsson-Langhammer, Elin M. Dahlin, Andreas B. |
author_sort | Malekian, Bita |
collection | PubMed |
description | Plasmonic nanostructures are widely used for various sensing applications by monitoring changes in refractive index through optical spectroscopy or as substrates for surface enhanced Raman spectroscopy. However, in most practical situations conventional surface plasmon resonance is preferred for biomolecular interaction analysis because of its high resolution in surface coverage and the simple single-material planar interface. Still, plasmonic nanostructures may find unique sensing applications, for instance when the nanoscale geometry itself is of interest. This calls for new methods to prepare nanoscale particles and cavities with controllable dimensions and curvature. In this work, we present two types of plasmonic nanopores where the solid support underneath a nanohole array has been etched, thereby creating cavities denoted as ‘nanowells’ or ‘nanocaves’ depending on the degree of anisotropy (dry or wet etch). The refractometric sensitivity is shown to be enhanced upon removing the solid support because of an increased probing volume and a shift of the asymmetric plasmonic field towards the liquid side of the finite gold film. Furthermore, the structures exhibit different spectral changes upon binding inside the cavities compared to the gold surface, which means that the structures can be used for location-specific detection. Other sensing applications are also suggested. |
format | Online Article Text |
id | pubmed-5492491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54924912017-07-03 Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support Malekian, Bita Xiong, Kunli Emilsson, Gustav Andersson, Jenny Fager, Cecilia Olsson, Eva Larsson-Langhammer, Elin M. Dahlin, Andreas B. Sensors (Basel) Article Plasmonic nanostructures are widely used for various sensing applications by monitoring changes in refractive index through optical spectroscopy or as substrates for surface enhanced Raman spectroscopy. However, in most practical situations conventional surface plasmon resonance is preferred for biomolecular interaction analysis because of its high resolution in surface coverage and the simple single-material planar interface. Still, plasmonic nanostructures may find unique sensing applications, for instance when the nanoscale geometry itself is of interest. This calls for new methods to prepare nanoscale particles and cavities with controllable dimensions and curvature. In this work, we present two types of plasmonic nanopores where the solid support underneath a nanohole array has been etched, thereby creating cavities denoted as ‘nanowells’ or ‘nanocaves’ depending on the degree of anisotropy (dry or wet etch). The refractometric sensitivity is shown to be enhanced upon removing the solid support because of an increased probing volume and a shift of the asymmetric plasmonic field towards the liquid side of the finite gold film. Furthermore, the structures exhibit different spectral changes upon binding inside the cavities compared to the gold surface, which means that the structures can be used for location-specific detection. Other sensing applications are also suggested. MDPI 2017-06-20 /pmc/articles/PMC5492491/ /pubmed/28632153 http://dx.doi.org/10.3390/s17061444 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Malekian, Bita Xiong, Kunli Emilsson, Gustav Andersson, Jenny Fager, Cecilia Olsson, Eva Larsson-Langhammer, Elin M. Dahlin, Andreas B. Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support |
title | Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support |
title_full | Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support |
title_fullStr | Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support |
title_full_unstemmed | Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support |
title_short | Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support |
title_sort | fabrication and characterization of plasmonic nanopores with cavities in the solid support |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492491/ https://www.ncbi.nlm.nih.gov/pubmed/28632153 http://dx.doi.org/10.3390/s17061444 |
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