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Management of soft tissue tumors of the upper extremity: a review

Introduction: Management of malignant tumors of the hand and wrist is challenging and is generally approached by limb salvage or amputation. With advances in care, amputation has been superseded by limb salvage as the treatment of choice. Methods: A narrative literature review was performed to ident...

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Autores principales: Jubbal, Kevin T., D’Souza, Gehaan, Abrams, Reid A., Kulidjian, Anna A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: EDP Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492789/
https://www.ncbi.nlm.nih.gov/pubmed/28664843
http://dx.doi.org/10.1051/sicotj/2017001
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author Jubbal, Kevin T.
D’Souza, Gehaan
Abrams, Reid A.
Kulidjian, Anna A.
author_facet Jubbal, Kevin T.
D’Souza, Gehaan
Abrams, Reid A.
Kulidjian, Anna A.
author_sort Jubbal, Kevin T.
collection PubMed
description Introduction: Management of malignant tumors of the hand and wrist is challenging and is generally approached by limb salvage or amputation. With advances in care, amputation has been superseded by limb salvage as the treatment of choice. Methods: A narrative literature review was performed to identify articles on the topic of management of soft tissue tumors of the upper extremity, including surgical management, adjuvant radiation therapy, and chemotherapy. Results: A total of 29 articles were selected. Earlier reports favored radical tumor resection, which often led to amputation, whereas later articles demonstrated limb salvage as the preferential treatment modality. Conclusions: Given the detrimental effects on function and psychologic outcomes, amputation has been superseded by limb salvage in most cases, although it can occasionally be the only option. A variety of adjuvant therapies have been described, including radiation or brachytherapy, chemotherapy, and regional hyperthermia. Radiation treatment, and specifically brachytherapy, is beneficial to select patients. Controversy surrounds chemotherapy in certain subtypes, and regional hyperthermia requires further investigation.
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spelling pubmed-54927892017-07-10 Management of soft tissue tumors of the upper extremity: a review Jubbal, Kevin T. D’Souza, Gehaan Abrams, Reid A. Kulidjian, Anna A. SICOT J Review Article Introduction: Management of malignant tumors of the hand and wrist is challenging and is generally approached by limb salvage or amputation. With advances in care, amputation has been superseded by limb salvage as the treatment of choice. Methods: A narrative literature review was performed to identify articles on the topic of management of soft tissue tumors of the upper extremity, including surgical management, adjuvant radiation therapy, and chemotherapy. Results: A total of 29 articles were selected. Earlier reports favored radical tumor resection, which often led to amputation, whereas later articles demonstrated limb salvage as the preferential treatment modality. Conclusions: Given the detrimental effects on function and psychologic outcomes, amputation has been superseded by limb salvage in most cases, although it can occasionally be the only option. A variety of adjuvant therapies have been described, including radiation or brachytherapy, chemotherapy, and regional hyperthermia. Radiation treatment, and specifically brachytherapy, is beneficial to select patients. Controversy surrounds chemotherapy in certain subtypes, and regional hyperthermia requires further investigation. EDP Sciences 2017-06-28 /pmc/articles/PMC5492789/ /pubmed/28664843 http://dx.doi.org/10.1051/sicotj/2017001 Text en © The Authors, published by EDP Sciences, 2017 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jubbal, Kevin T.
D’Souza, Gehaan
Abrams, Reid A.
Kulidjian, Anna A.
Management of soft tissue tumors of the upper extremity: a review
title Management of soft tissue tumors of the upper extremity: a review
title_full Management of soft tissue tumors of the upper extremity: a review
title_fullStr Management of soft tissue tumors of the upper extremity: a review
title_full_unstemmed Management of soft tissue tumors of the upper extremity: a review
title_short Management of soft tissue tumors of the upper extremity: a review
title_sort management of soft tissue tumors of the upper extremity: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492789/
https://www.ncbi.nlm.nih.gov/pubmed/28664843
http://dx.doi.org/10.1051/sicotj/2017001
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