Stimulation of Adenosine A(2B) Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway

Background and Purpose: Cardiac fibrosis is characterized by an increase in fibroblast proliferation, overproduction of extracellular matrix proteins, and the formation of myofibroblast that express α-smooth muscle actin (α-SMA). Endothelin-1 (ET-1) is involved in the pathogenesis of cardiac fibrosi...

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Detalles Bibliográficos
Autores principales: Phosri, Sarawuth, Arieyawong, Ajaree, Bunrukchai, Kwanchai, Parichatikanond, Warisara, Nishimura, Akiyuki, Nishida, Motohiro, Mangmool, Supachoke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492828/
https://www.ncbi.nlm.nih.gov/pubmed/28713274
http://dx.doi.org/10.3389/fphar.2017.00428

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